Hypothermic oxygenated new machine perfusion system in liver and kidney transplantation of extended criteria donors: first Italian clinical trial

M Ravaioli, V De Pace, A Angeletti, G Comai… - Scientific reports, 2020 - nature.com
With the aim to explore innovative tools for organ preservation, especially in marginal
organs, we hereby describe a clinical trial of ex-vivo hypothermic oxygenated perfusion …

[HTML][HTML] Ex-vivo Kidney Machine Perfusion: Therapeutic Potential

R Zulpaite, P Miknevicius, B Leber, K Strupas… - Frontiers in …, 2021 - frontiersin.org
Kidney transplantation remains the gold standard treatment for patients suffering from end-
stage kidney disease. To meet the constantly growing organ demands grafts donated after …

The future of organ perfusion and re‐conditioning

A Weissenbacher, G Vrakas, D Nasralla… - Transplant …, 2019 - Wiley Online Library
Organ preservation and re‐conditioning using machine perfusion technologies continue to
generate promising results in terms of viability assessment, organ utilization and improved …

[HTML][HTML] Protocol of a randomised controlled, open-label trial of ex vivo normothermic perfusion versus static cold storage in donation after circulatory death renal …

SA Hosgood, K Saeb-Parsy, C Wilson, C Callaghan… - BMJ open, 2017 - bmjopen.bmj.com
Introduction Ex vivo normothermic perfusion (EVNP) is a novel technique that reconditions
the kidney and restores renal function prior to transplantation. Phase I data from a series of …

[HTML][HTML] Twenty-four–hour normothermic perfusion of discarded human kidneys with urine recirculation

A Weissenbacher, LL Faro, O Boubriak… - American Journal of …, 2019 - Elsevier
Transportable normothermic kidney perfusion for 24 hours or longer could enable viability
assessment of marginal grafts, increased organ use, and improved transplant logistics …

Review of current machine perfusion therapeutics for organ preservation

J Xu, JE Buchwald, PN Martins - Transplantation, 2020 - journals.lww.com
Because of the high demand of organs, the usage of marginal grafts has increased. These
marginal organs have a higher risk of developing ischemia-reperfusion injury, which can …

Nanoparticle targeting to the endothelium during normothermic machine perfusion of human kidneys

GT Tietjen, SA Hosgood, J DiRito, J Cui… - Science translational …, 2017 - science.org
Ex vivo normothermic machine perfusion (NMP) is a new clinical strategy to assess and
resuscitate organs likely to be declined for transplantation, thereby increasing the number of …

Normothermic ex vivo kidney perfusion for human kidney transplantation: first North American results

LI Mazilescu, P Urbanellis, SJ Kim, T Goto… - …, 2022 - journals.lww.com
Background. Normothermic ex vivo kidney perfusion (NEVKP) has shown promising results
for preservation, assessment, and reconditioning of kidney allografts in preclinical studies …

[HTML][HTML] Normothermic kidney perfusion: An overview of protocols and strategies

TR Elliott, ML Nicholson, SA Hosgood - American Journal of …, 2021 - Elsevier
Normothermic machine perfusion (NMP) technologies are emerging as an important adjunct
in organ preservation and transplantation. NMP can enable the reduction or avoidance of …

Mitochondria as therapeutic targets in transplantation

K Saeb-Parsy, JL Martin, DM Summers… - Trends in molecular …, 2021 - cell.com
Advances in surgical procedures, technology, and immune suppression have transformed
organ transplantation. However, the metabolic changes that occur during organ retrieval …