As the lung is constantly exposed to both innocuous and potentially noxious antigens, a
thorough understanding of both innate and adaptive immune responses in this organ is of …

Background Jawoongo is an herbal mixture used in traditional medicine to treat skin
diseases. This study aimed to investigate whether Jawoongo ameliorates Atopic dermatitis …

METHODS: We performed Cellular Indexing of Transcriptomes and Epitopes by sequencing
on peripheral blood, colon, and ileal immune cells derived from healthy subjects and …

Background Single nucleotide polymorphisms (SNPs) influence a patient's response to
inhaled corticosteroids and β 2-agonists, and the effect of treatment with inhaled …

Highlights•Inhalation of subway PM 2.5 causes pulmonary inflammation.•Lung scRNA-seq
depicts cell-specific responses in mice by subway PM 2.5.•scRNA-seq highlights roles of …

Background Sex differences related to immune responses can influence atopic
manifestations in childhood asthma. While genome-wide association studies have …

Abstract Recombination-activating gene 1 (Rag1) and Rag2 enzymes are required for T cell
receptor assembly and thymocyte development. The mechanisms underlying the …

An original bioinformatics technique is developed to identify the protein-coding genes in
rodents, lagomorphs and nonhuman primates that are pseudogenized in humans. The …

Background Late-onset asthma (LOA) has distinct characteristics and its pathogenesis might
rely on unique pathways. Although current studies are focused primarily on childhood …

The rapid pace of drug development in recent years has led to the recognition that new
pharmacotherapies do not have the same effect on all patients. This is particularly true in the …