Central to the debate about cancer stem cells in solid tumors is the proportion of cells that
can initiate, propagate, and re-initiate tumors. An initially assumed minor subpopulation is …

Evolutionary mechanisms in cancer progression give tumors their individuality. Cancer
evolution is different from organismal evolution, however, and we discuss where concepts …

Intraperitoneal dissemination of ovarian cancers is preceded by the development of
chemoresistant tumors with malignant ascites. Despite the high levels of chemoresistance …

Tumors are appreciated to be an intrinsically heterogeneous population of cells with varying
proliferation capacities and tumorigenic potentials. As a central tenet of the so-called cancer …

In recent years cancer stem cells (CSCs) have been hypothesized to comprise only a minor
subpopulation in solid tumors that drives tumor initiation, progression, and metastasis; the so …

Hierarchical organized tissue structures, with stem cell driven cell differentiation, are critical
to the homeostatic maintenance of most tissues, and this underlying cellular architecture is …

Targeting key regulators of the cancer stem cell phenotype to overcome their critical
influence on tumor growth is a promising new strategy for cancer treatment. Here we present …

It is very important to understand the onset and growth pattern of breast primary tumours as
well as their metastatic dissemination. In most cases, it is the metastatic disease that …

The dramatical development of Web-based technology has been empowering enormous
change in various domains. Cloud-based solutions have remarkably widened business …

This article reviews the application of information-theoretical analysis, employing measures
of entropy and mutual information, for the study of aging and aging-related diseases. The …