Chemical reprogramming offers an unprecedented opportunity to control somatic cell fate
and generate desired cell types including pluripotent stem cells for applications in …

Over the past few decades, many attempts have been made to capture different states of
pluripotency in vitro. Naive and primed pluripotent stem cells, corresponding to the …

Highlights•Cellular models can recapitulate some aspects of embryonic genome
activation.•Multiple factors regulate embryonic genome activation.•Several types of totipotent …

Studies of mammalian development have advanced our understanding of the genetic,
epigenetic, and cellular processes that orchestrate embryogenesis and have uncovered …

Although parental genomes undergo extensive epigenetic reprogramming to be equalized
after fertilization, whether they play different roles in human zygotic genome activation (ZGA) …

Early embryo development is a highly dynamic process that plays a crucial role in
determining the health and characteristics of an organism. For many years, embryonic and …

The totipotent embryo initiates transcription during zygotic or embryonic genome activation
(EGA, ZGA). ZGA occurs at the 8-cell stage in humans and its failure leads to developmental …

Highlights•Human dosage compensation mechanisms cannot be adequately modeled in
mice.•Naive human pluripotent stem cells (hPSCs) model X-chromosome dampening.•Naive …

Embryonic genome activation (EGA) occurs during preimplantation development and is
characterized by the initiation of de novo transcription from the embryonic genome. Despite …

Aneuploidy is frequently detected in early human embryos as a major cause of early
pregnancy failure. However, how aneuploidy affects cellular function remains elusive. Here …