For almost two decades, cell-based therapies have been tested in modern regenerative
medicine to either replace or regenerate human cells, tissues, or organs and restore normal …

In recent years, several studies have reported positive outcomes of cell-based therapies
despite insufficient engraftment of transplanted cells. These findings have created a huge …

We previously showed that, when peripheral blood mononuclear cells (PBMCs) were
stressed with ionizing radiation, they released paracrine factors that showed regenerative …

Myocarditis is an inflammatory cardiovascular disease which contributes to dilated
cardiomyopathy (DCM) and heart failure. Canagliflozin (CANA) exerts anti-inflammatory and …

Sacubitril/valsartan (Sac/Val) is a recently approved drug that is commonly used for
treatment of heart failure. Several studies indicated that Sac/Val also regulated the secretion …

After spinal cord injury (SCI), secondary damage caused by oxidative stress, inflammation,
and ischemia leads to neurological deterioration. In recent years, therapeutic approaches to …

Burn wounds pose a serious threat to patients and often require surgical treatment. Skin
grafting aims to achieve wound closure but requires a well-vascularized wound bed. The …

Secretomes from various cell sources exert strong regenerative activities on numerous
organs, including the skin. Although secretomes consist of many diverse components, a …

Background High dose ionizing radiation (IR) induces potent toxic cell effects mediated by
either direct DNA damage or the production of reactive oxygen species (ROS). IR-induced …

CD4+ T cells undergo immunometabolic activation to mount an immunogenic response
during experimental autoimmune myocarditis (EAM). Exosomes are considered key …