International union of pharmacology. XXIII. The angiotensin II receptors
M De Gasparo, KJ Catt, T Inagami, JW Wright… - Pharmacological …, 2000 - ASPET
The cardiovascular and other actions of angiotensin II (Ang II) are mediated by AT1 and AT2
receptors, which are seven transmembrane glycoproteins with 30% sequence similarity …
receptors, which are seven transmembrane glycoproteins with 30% sequence similarity …
Brain and pituitary angiotensin
JM Saavedra - Endocrine reviews, 1992 - academic.oup.com
I. Introduction A ngiotensin (ANG II) was discovered about 50 yr ago (1, 2), and a complete
peripheral system for the formation and metabolism of ANG II was soon characterized. It was …
peripheral system for the formation and metabolism of ANG II was soon characterized. It was …
Tissue renin-angiotensin systems: new insights from experimental animal models in hypertension research
M Bader, J Peters, O Baltatu, DN Müller, FC Luft… - Journal of molecular …, 2001 - Springer
Renin was first isolated in the kidney by Tigerstedt and Bergman over 100 years ago. Almost
50 additional years were necessary to isolate the renin substrate angiotensinogen and to …
50 additional years were necessary to isolate the renin substrate angiotensinogen and to …
Angiotensin II in central nervous system physiology
MI Phillips, C Sumners - Regulatory peptides, 1998 - Elsevier
1. Introduction direct injection of Ang II into the rat brain produced drinking behavior [9] and
indirect measurements showing Exactly one hundred years ago Tiegerstedt and Bergman …
indirect measurements showing Exactly one hundred years ago Tiegerstedt and Bergman …
Regulatory role of brain angiotensins in the control of physiological and behavioral responses
JW Wright, JW Harding - Brain Research Reviews, 1992 - Elsevier
Considerable evidence now indicates that a separate and distinct renin-angiotensin system
(RAS) is present within the brain. The necessary precursors and enzymes required for the …
(RAS) is present within the brain. The necessary precursors and enzymes required for the …
Antisense inhibition of AT1 receptor mRNA and angiotensinogen mRNA in the brain of spontaneously hypertensive rats reduces hypertension of neurogenic origin
R Gyurko, D Wielbo, MI Phillips - Regulatory peptides, 1993 - Elsevier
To determine the role of angiotensinogen and angiotensin II type-1 (AT1) receptor genes in
hypertension, spontaneously hypertensive rats (SHR) were injected with synthetic antisense …
hypertension, spontaneously hypertensive rats (SHR) were injected with synthetic antisense …
Brain renin-angiotensin system in the pathophysiology of cardiovascular diseases
G Huber, F Schuster, W Raasch - Pharmacological research, 2017 - Elsevier
Cardiovascular diseases (CVD) are among the main causes of death globally and in this
context hypertension represents one of the key risk factors for developing a CVD. It is well …
context hypertension represents one of the key risk factors for developing a CVD. It is well …
The role of the brain renin–angiotensin system in hypertension: implications for new treatment
Y Marc, C Llorens-Cortes - Progress in neurobiology, 2011 - Elsevier
Hypertension affects 26% of adults and is in constant progress related to increased
incidence of obesity and diabetes. One-third of hypertensive patients may be successfully …
incidence of obesity and diabetes. One-third of hypertensive patients may be successfully …
Autoradiographic localization of subtypes of angiotensin II antagonist binding in the rat brain
DR Gehlert, SL Gackenheimer, DA Schober - Neuroscience, 1991 - Elsevier
The non-peptide angiotensin II receptor compounds DuP 753 and WL 19 were utilized to
detect subtypes of [125 I] Sar 1-Ile 8-angiotensin II binding to angiotensin II receptors in the …
detect subtypes of [125 I] Sar 1-Ile 8-angiotensin II binding to angiotensin II receptors in the …
Elevated blood pressure in transgenic mice with brain-specific expression of human angiotensinogen driven by the glial fibrillary acidic protein promoter
S Morimoto, MD Cassell, TG Beltz, AK Johnson… - Circulation …, 2001 - Am Heart Assoc
In addition to the circulatory renin (REN)–angiotensin system (RAS), a tissue RAS having an
important role in cardiovascular function also exists in the central nervous system. In the …
important role in cardiovascular function also exists in the central nervous system. In the …