Review of the endocannabinoid system

HC Lu, K Mackie - Biological Psychiatry: Cognitive Neuroscience and …, 2021 - Elsevier
The endocannabinoid system (ECS) is a widespread neuromodulatory network involved in
the developing central nervous system as well as playing a major role in tuning many …

Therapeutic potential of cannabis, cannabidiol, and cannabinoid-based pharmaceuticals

CA Legare, WM Raup-Konsavage, KE Vrana - Pharmacology, 2022 - karger.com
Background: There is a growing interest in the use of cannabis (and its extracts), as well as
CBD oil (hemp extracts containing cannabidiol), for therapeutic purposes. While there is …

Association of cannabis potency with mental ill health and addiction: a systematic review

K Petrilli, S Ofori, L Hines, G Taylor, S Adams… - The Lancet …, 2022 - thelancet.com
Cannabis potency, defined as the concentration of Δ 9-tetrahydrocannabinol (THC), has
increased internationally, which could increase the risk of adverse health outcomes for …

The pharmacokinetics and the pharmacodynamics of cannabinoids

CJ Lucas, P Galettis, J Schneider - British journal of clinical …, 2018 - Wiley Online Library
There is increasing interest in the use of cannabinoids for disease and symptom
management, but limited information available regarding their pharmacokinetics and …

Changes in delta‐9‐tetrahydrocannabinol (THC) and cannabidiol (CBD) concentrations in cannabis over time: systematic review and meta‐analysis

TP Freeman, S Craft, J Wilson, S Stylianou… - …, 2021 - Wiley Online Library
Background and aims Cannabis products with high delta‐9‐tetrahydrocannabinol (THC)
concentrations carry an increased risk of addiction and mental health disorders, while it has …

Early evidence of the impact of cannabis legalization on cannabis use, cannabis use disorder, and the use of other substances: Findings from state policy evaluations

R Smart, RL Pacula - The American journal of drug and alcohol …, 2019 - Taylor & Francis
Background: The past decade has seen unprecedented shifts in the cannabis policy
environment, and the public health impacts of these changes will hinge on how they affect …

Medicinal cannabis for psychiatric disorders: a clinically-focused systematic review

J Sarris, J Sinclair, D Karamacoska, M Davidson, J Firth - BMC psychiatry, 2020 - Springer
Background Medicinal cannabis has received increased research attention over recent
years due to loosening global regulatory changes. Medicinal cannabis has been reported to …

An introduction to the endogenous cannabinoid system

HC Lu, K Mackie - Biological psychiatry, 2016 - Elsevier
The endocannabinoid system (ECS) is a widespread neuromodulatory system that plays
important roles in central nervous system development, synaptic plasticity, and the response …

Results from the Colorado Cannabis Users Survey on Health (CUSH), 2016

AE Contreras, KE Hall, DI Vigil, A Rosenthal… - International Journal of …, 2020 - Springer
Patterns of cannabis consumption among regular users within a legalized environment have
not been explored in detail. We aimed to conduct a survey among regular cannabis users to …

Effects of cannabis use on human behavior, including cognition, motivation, and psychosis: a review

ND Volkow, JM Swanson, AE Evins, LE DeLisi… - JAMA …, 2016 - jamanetwork.com
With a political debate about the potential risks and benefits of cannabis use as a backdrop,
the wave of legalization and liberalization initiatives continues to spread. Four states …