Organismal aging exhibits wide-ranging hallmarks in divergent cell types across tissues,
organs, and systems. The advancement of single-cell technologies and generation of rich …

Functional molecular characterization of the cochlea has mainly been driven by the
deciphering of the genetic architecture of sensorineural deafness. As a result, the search for …

The liver is one of the few organs that retain the capability to regenerate in adult mammals.
This regeneration process is mainly facilitated by the dynamic behavior of hepatocytes …

Oxidative protein folding occurs in the endoplasmic reticulum (ER) to generate disulfide
bonds, and the by‐product is hydrogen peroxide (H2O2). However, the relationship between …

Ageing is a critical factor in spinal-cord-associated disorders, yet the ageing-specific
mechanisms underlying this relationship remain poorly understood. Here, to address this …

Regeneration across tissues and organs exhibits significant variation throughout the body
and undergoes a progressive decline with age. To decode the relationships between aging …

The ovary is indispensable for female reproduction, and its age-dependent functional
decline is the primary cause of infertility. However, the molecular basis of ovarian aging in …

Organ degeneration refers to the gradual decline in organ function and structure
deterioration that occurs during aging, which represents the greatest risk factor for various …

Aging is associated with progressive physiological decline and biological dysfunction, which
is therefore considered a major risk factor for age-related chronic diseases, such as …

Age-related hearing loss (ARHL) is the most common sensory degenerative disease and
can significantly impact the quality of life in elderly people. A previous study using GeneChip …