[HTML][HTML] Advances in understanding N-glycosylation structure, function, and regulation in health and disease

S Esmail, MF Manolson - European journal of cell biology, 2021 - Elsevier
N-linked glycosylation is a post-translational modification crucial for membrane protein
folding, stability and other cellular functions. Alteration of membrane protein N-glycans is …

[HTML][HTML] Hallmarks of glycosylation in cancer

J Munkley, DJ Elliott - Oncotarget, 2016 - ncbi.nlm.nih.gov
Aberrant glycosylation plays a fundamental role in key pathological steps of tumour
development and progression. Glycans have roles in cancer cell signalling, tumour cell …

[HTML][HTML] Cancer exosomes perform cell-independent microRNA biogenesis and promote tumorigenesis

SA Melo, H Sugimoto, JT O'Connell, N Kato… - Cancer cell, 2014 - cell.com
Exosomes are secreted by all cell types and contain proteins and nucleic acids. Here, we
report that breast cancer associated exosomes contain microRNAs (miRNAs) associated …

Intrinsic disorder and posttranslational modifications: the darker side of the biological dark matter

AL Darling, VN Uversky - Frontiers in genetics, 2018 - frontiersin.org
Intrinsically disordered proteins (IDPs) and intrinsically disordered protein regions (IDPRs)
are functional proteins and domains that devoid stable secondary and/or tertiary structure …

Roles of proteoglycans and glycosaminoglycans in cancer development and progression

J Wei, M Hu, K Huang, S Lin, H Du - International journal of molecular …, 2020 - mdpi.com
The extracellular matrix (ECM) spatiotemporally controls cell fate; however, dysregulation of
ECM remodeling can lead to tumorigenesis and cancer development by providing favorable …

Current Methods for the Characterization of O-Glycans

H Wilkinson, R Saldova - Journal of proteome research, 2020 - ACS Publications
Glycosylation is crucial in cellular metabolism and survival. Of interest is the role of N-linked
and O-linked glycans in disease states. Robust analytical methods must be defined to …

[HTML][HTML] Aberrant protein glycosylation: Implications on diagnosis and Immunotherapy

R Bangarh, C Khatana, S Kaur, A Sharma… - Biotechnology …, 2023 - Elsevier
Glycosylation-mediated post-translational modification is critical for regulating many
fundamental processes like cell division, differentiation, immune response, and cell-to-cell …

The diverse contributions of fucose linkages in cancer

TS Keeley, S Yang, E Lau - Cancers, 2019 - mdpi.com
Fucosylation is a post-translational modification of glycans, proteins, and lipids that is
responsible for many biological processes. Fucose conjugation via α (1, 2), α (1, 3), α (1, 4) …

Targeted photodynamic therapy of breast cancer cells using lactose-phthalocyanine functionalized gold nanoparticles

PG Calavia, I Chambrier, MJ Cook, AH Haines… - Journal of colloid and …, 2018 - Elsevier
Gold nanoparticles (AuNPs), which have been widely used for the delivery of
photosensitizers for photodynamic therapy (PDT) of cancer, can be dispersed in aqueous …

The evolving role of MUC16 (CA125) in the transformation of ovarian cells and the progression of neoplasia

P Giamougiannis, PL Martin-Hirsch, FL Martin - Carcinogenesis, 2021 - academic.oup.com
MUC16 (the cancer antigen CA125) is the most commonly used serum biomarker in
epithelial ovarian cancer, with increasing levels reflecting disease progression. It is a …