Oxidative stress (OS) is regarded as the dominant theory for aging. While compelling
correlative data have been generated to support the OS theory, a direct cause-and-effect …

Despite tremendous efforts in basic research and a growing number of clinical trials aiming
to find effective treatments, amyotrophic lateral sclerosis (ALS) remains an incurable …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease targeting the brain and
spinal cord. Non-neuronal cells, including macrophages, may contribute to the disruption of …

Familial amyotrophic lateral sclerosis (ALS) is a progressive neuromuscular disorder that is
due to mutations in one of several target genes, including SOD1. So far, clinical records …

Extracellular vesicles (EVs), including exosomes and microvesicles, are membrane-bound
particles released by cells into extracellular space. These vesicles carry various molecules …