The present study aimed to explore the contribution of mammalian target of rapamycin
(mTOR) in deoxycorticosterone acetate (DOCA) salt–induced hypertension and related …

Ultraviolet (UV) exposure to the human skin reduces triglycerides contents and lipid
synthesis in the subcutaneous (SC) fat. Because adiponectin and leptin are the most …

Obesity is accompanied by metabolic alterations characterized by insulin resistance and
cardiac lipotoxicity. Galectin-3 (Gal-3) induces cardiac inflammation and fibrosis in the …

Leptin is a small peptide mainly secreted by adipocyte, which acts on the central nervous
system of the hypothalamus to regulate the body's energy balance by inhibiting food intake …

Cardiac fibrosis is a hallmark of various cardiovascular diseases, which is quite commonly
found in obesity, and may contribute to the increased incidence of heart failure arrhythmias …

The aim of the present study was to evaluate the effect of Compound 21 (C21), a selective
AT2R agonist, on the prevention of endothelial dysfunction, extracellular matrix (ECM) …

Diabetes-mediated hyperglycemia is a major risk factor for renal fibrosis, resulting in the
development of chronic kidney diseases. To address this issue, the effect of melatonin …

Background. Obesity is related to coronary artery disease (CAD) and worse outcomes in
coronary artery bypass graft (CABG) patients. Adipose tissue itself is an endocrine organ …

Aims Activation of cardiac fibroblasts into myofibroblasts constitutes a key step in cardiac
remodeling after myocardial infarction (MI), due to interstitial fibrosis. Mesenchymal stem …

Transforming growth factor beta (Tgfb) is a well-studied pro-fibrotic cytokine, which
upregulates cellular communication network factor 2 (Ccn2), collagen, and actin alpha 2 …