miR‑122 and miR‑199 synergistically promote autophagy in oral lichen planus by targeting the Akt/mTOR pathway

L Wang, W Wu, J Chen, Y Li… - … journal of molecular …, 2019 - spandidos-publications.com
The aim of the present study was to characterize the roles of two microRNAs (miRNAs), miR‑
122 and miR‑199, in oral lichen planus (OLP). miRNA microarray analysis was performed to …

[HTML][HTML] TGF-β: The missing link in obesity-associated airway diseases?

J Woo, C Koziol-White, R Panettieri Jr, J Jude - Current research in …, 2021 - Elsevier
Obesity is emerging as a global public health epidemic. The co-morbidities associated with
obesity significantly contribute to reduced quality of life, mortality, and global healthcare …

Preoperative plasma aldosterone and the risk of atrial fibrillation after coronary artery bypass surgery: a prospective cohort study

J Alexandre, E Saloux, M Chequel… - Journal of …, 2016 - journals.lww.com
Objective: Postoperative atrial fibrillation (POAF) is associated with poor outcomes after
coronary artery bypass graft (CABG) surgery. We aimed to assess the additional value of …

Arterial stiffness is associated with adipokine dysregulation in non-hypertensive obese mice

M Gil-Ortega, M Martín-Ramos, SM Arribas… - Vascular …, 2016 - Elsevier
The aim of this study was to characterize alterations in vascular structure and mechanics in
murine mesenteric arteries from obese non-hypertensive mice, as well as their relationship …

MicroRNA expression signature is altered in the cardiac remodeling induced by high fat diets

EC Guedes, GS Franca, CA Lino… - Journal of cellular …, 2016 - Wiley Online Library
Recent studies have revealed the involvement of microRNAs (miRNAs) in the control of
cardiac hypertrophy and myocardial function. In addition, several reports have demonstrated …

Secreted Phospholipase A2-IIA Modulates Transdifferentiation of Cardiac Fibroblast through EGFR Transactivation: An Inflammation–Fibrosis Link

R Martin, B Gutierrez, C Cordova, A San Roman… - Cells, 2020 - mdpi.com
Secreted phospholipase A2-IIA (sPLA2-IIA) is a pro-inflammatory protein associated with
cardiovascular disorders, whose functions and underlying mechanisms in cardiac …

Mitochondrial oxidative stress induces cardiac fibrosis in obese rats through modulation of transthyretin

E Martínez-Martínez, J Fernández-Irigoyen… - International Journal of …, 2022 - mdpi.com
A proteomic approach was used to characterize potential mediators involved in the
improvement in cardiac fibrosis observed with the administration of the mitochondrial …

Interleukin-33/ST2 system attenuates aldosterone-induced adipogenesis and inflammation

E Martínez-Martínez, V Cachofeiro, E Rousseau… - Molecular and cellular …, 2015 - Elsevier
Abstract Interleukin-33 (IL-33) but not soluble ST2 (sST2) exerts anti-inflammatory and
protective effects in several tissues. Aldosterone, a proinflammatory mediator which …

The conundrum of patients with obesity, exercise intolerance, elevated ventricular filling pressures and a measured ejection fraction in the normal range

M Packer - European Journal of Heart Failure, 2019 - Wiley Online Library
Patients with obesity, a reduced exercise capacity, increased cardiac filling pressures and a
measured left ventricular ejection fraction in the normal range do not have a homogeneous …

Moderate aerobic exercise increases SOD-2 gene expression and decreases leptin and malondialdehyde in middle-aged men

B Baghaiee, AMB Teixeira, B Tartibian - Science & Sports, 2016 - Elsevier
Objectives The purpose of the this study was to investigate the effect of two months of
moderate aerobic exercise training on the relationship between serum leptin concentration …