Affinity maturation of antibody fragments: A review encompassing the development from random approaches to computational rational optimization
J Li, G Kang, J Wang, H Yuan, Y Wu, S Meng… - International journal of …, 2023 - Elsevier
Routinely screened antibody fragments usually require further in vitro maturation to achieve
the desired biophysical properties. Blind in vitro strategies can produce improved ligands by …
the desired biophysical properties. Blind in vitro strategies can produce improved ligands by …
[HTML][HTML] Analysis of the conserved protective epitopes of hemagglutinin on influenza A viruses
C Jiao, B Wang, P Chen, Y Jiang, J Liu - Frontiers in Immunology, 2023 - frontiersin.org
The conserved protective epitopes of hemagglutinin (HA) are essential to the design of a
universal influenza vaccine and new targeted therapeutic agents. Over the last 15 years …
universal influenza vaccine and new targeted therapeutic agents. Over the last 15 years …
Preclinical animal models to evaluate therapeutic antiviral antibodies
A De Meyer, P Meuleman - Antiviral Research, 2024 - Elsevier
Despite the availability of effective preventative vaccines and potent small-molecule antiviral
drugs, effective non-toxic prophylactic and therapeutic measures are still lacking for many …
drugs, effective non-toxic prophylactic and therapeutic measures are still lacking for many …
[HTML][HTML] Preparation and characterization of mouse-derived monoclonal antibodies against the hemagglutinin of the H1N1 influenza virus
X Lin, F Yang, S Yan, H Wu, P Wang, Y Zhao, D Shi… - Virus Research, 2024 - Elsevier
H1N1 influenza virus is a significant global public health concern. Monoclonal antibodies
(mAbs) targeting specific viral proteins such as hemagglutinin (HA) have become an …
(mAbs) targeting specific viral proteins such as hemagglutinin (HA) have become an …
[HTML][HTML] The generation of hemagglutinin monoclonal antibodies against H9N2 influenza virus
Y Duan, Q Guo, S Tu, J Zou, G Li, C Liang, Y Cheng… - Animal Diseases, 2023 - Springer
H9N2 avian influenza viruses (AIVs) are widely distributed, causing continuous outbreaks in
poultry and sporadic infections in humans. Vaccination is the primary method used to …
poultry and sporadic infections in humans. Vaccination is the primary method used to …