DNA methylation dynamics in health and disease
Y Bergman, H Cedar - Nature structural & molecular biology, 2013 - nature.com
DNA methylation is an epigenetic mark that is erased in the early embryo and then re-
established at the time of implantation. In this Review, dynamics of DNA methylation during …
established at the time of implantation. In this Review, dynamics of DNA methylation during …
DNA methylation and gene function
A Razin, AD Riggs - Science, 1980 - science.org
In most higher organisms, DNA is modified after synthesis by the enzymatic conversion of
many cytosine residues to 5-methylcytosine. For several years, control of gene activity by …
many cytosine residues to 5-methylcytosine. For several years, control of gene activity by …
Programming of DNA methylation patterns
H Cedar, Y Bergman - Annual review of biochemistry, 2012 - annualreviews.org
DNA methylation represents a form of genome annotation that mediates gene repression by
serving as a maintainable mark that can be used to reconstruct silent chromatin following …
serving as a maintainable mark that can be used to reconstruct silent chromatin following …
Developmental pattern of gene-specific DNA methylation in the mouse embryo and germ line.
Methylation patterns of specific genes have been studied by polymerase chain reaction and
found to undergo dynamic changes in the germ line and early embryo. Some CpG sites are …
found to undergo dynamic changes in the germ line and early embryo. Some CpG sites are …
DNA methylation affects the formation of active chromatin
I Keshet, J Lieman-Hurwitz, H Cedar - Cell, 1986 - cell.com
To study the mechanism of gene repression by DNA methylation, Ml3 gene constructs were
methylated to completion and inserted into mouse L cells by DNA-mediated gene transfer …
methylated to completion and inserted into mouse L cells by DNA-mediated gene transfer …
Characterization of the level, target sites and inheritance of cytosine methylation in tomato nuclear DNA
R Messeguer, MW Ganal, JC Steffens… - Plant Molecular …, 1991 - Springer
The tomato nuclear genome was determined to have a G+ C content of 37% which is among
the lowest reported for any plant species. Non-coding regions have a G+ C content even …
the lowest reported for any plant species. Non-coding regions have a G+ C content even …
Genetic implications of somaclonal variation in plants
VM Peschke, RL Phillips - Advances in genetics, 1992 - Elsevier
Publisher Summary This chapter discusses the genetic implications of somaclonal variation
in plants. The chapter investigates the topic of somaclonal variation from two perspectives …
in plants. The chapter investigates the topic of somaclonal variation from two perspectives …
Tissue culture-induced variation and crop improvement
RR Duncan - Advances in agronomy, 1996 - Elsevier
Publisher Summary The selection of regenerants with good agronomic performance
depends on the relative effects of induced and introduced variation during the in vitro …
depends on the relative effects of induced and introduced variation during the in vitro …
Zebra fish Dnmt1 and Suv39h1 regulate organ-specific terminal differentiation during development
K Rai, LD Nadauld, S Chidester, EJ Manos… - … and cellular biology, 2006 - Taylor & Francis
DNA methylation and histone methylation are two key epigenetic modifications that help
govern heterochromatin dynamics. The roles for these chromatin-modifying activities in …
govern heterochromatin dynamics. The roles for these chromatin-modifying activities in …
Infection with human immunodeficiency virus type 1 upregulates DNA methyltransferase, resulting in de novo methylation of the gamma interferon (IFN-γ) promoter …
JA Mikovits, HA Young, P Vertino, JPJ Issa… - … and cellular biology, 1998 - Am Soc Microbiol
The immune response to pathogens is regulated by a delicate balance of cytokines. The
dysregulation of cytokine gene expression, including interleukin-12, tumor necrosis factor …
dysregulation of cytokine gene expression, including interleukin-12, tumor necrosis factor …