Recent strategies to develop innovative photosensitizers for enhanced photodynamic therapy

TC Pham, VN Nguyen, Y Choi, S Lee, J Yoon - Chemical reviews, 2021 - ACS Publications
This review presents a robust strategy to design photosensitizers (PSs) for various species.
Photodynamic therapy (PDT) is a photochemical-based treatment approach that involves the …

Transition metal complexes and photodynamic therapy from a tumor-centered approach: challenges, opportunities, and highlights from the development of TLD1433

S Monro, KL Colon, H Yin, J Roque III, P Konda… - Chemical …, 2018 - ACS Publications
Transition metal complexes are of increasing interest as photosensitizers in photodynamic
therapy (PDT) and, more recently, for photochemotherapy (PCT). In recent years, Ru (II) …

Targeted photoredox catalysis in cancer cells

H Huang, S Banerjee, K Qiu, P Zhang, O Blacque… - Nature …, 2019 - nature.com
Hypoxic tumours are a major problem for cancer photodynamic therapy. Here, we show that
photoredox catalysis can provide an oxygen-independent mechanism of action to combat …

Stimuli-responsive therapeutic metallodrugs

X Wang, X Wang, S Jin, N Muhammad, Z Guo - Chemical reviews, 2018 - ACS Publications
The success of platinum-based anticancer agents has motivated the exploration of novel
metal-based drugs for several decades, whereas problems such as drug-resistance and …

Critical overview of the use of Ru (II) polypyridyl complexes as photosensitizers in one-photon and two-photon photodynamic therapy

F Heinemann, J Karges, G Gasser - Accounts of chemical …, 2017 - ACS Publications
Conspectus Photodynamic Therapy (PDT) is an emerging technique to treat certain types of
cancer, bacterial, fungal, and viral infections, and skin diseases. In past years, different …

The development of ruthenium (II) polypyridyl complexes and conjugates for in vitro cellular and in vivo applications

FE Poynton, SA Bright, S Blasco, DC Williams… - Chemical Society …, 2017 - pubs.rsc.org
Ruthenium (II)[Ru (II)] polypyridyl complexes have been the focus of intense investigations
since work began exploring their supramolecular interactions with DNA. In recent years …

Transition metal complexes as photosensitisers in one-and two-photon photodynamic therapy

LK McKenzie, HE Bryant, JA Weinstein - Coordination Chemistry Reviews, 2019 - Elsevier
Photodynamic therapy (PDT) exploits light-activated compounds for therapeutic use. It relies
on a photosensitiser (PS) that is inactive in the absence of light. When irradiated, the PS …

A mitochondria‐targeted photosensitizer showing improved photodynamic therapy effects under hypoxia

W Lv, Z Zhang, KY Zhang, H Yang, S Liu… - Angewandte Chemie …, 2016 - Wiley Online Library
Organelle‐targeted photosensitizers have been reported to be effective photodynamic
therapy (PDT) agents. In this work, we designed and synthesized two iridium (III) complexes …

Combination of Ru (II) complexes and light: new frontiers in cancer therapy

C Mari, V Pierroz, S Ferrari, G Gasser - Chemical science, 2015 - pubs.rsc.org
The synergistic action of light, oxygen and a photosensitizer (PS) has found applications for
decades in medicine under the name of photodynamic therapy (PDT) for the treatment of …

Highly charged ruthenium (II) polypyridyl complexes as lysosome‐localized photosensitizers for two‐photon photodynamic therapy

H Huang, B Yu, P Zhang, J Huang… - Angewandte Chemie …, 2015 - Wiley Online Library
Photodynamic therapy (PDT) is a noninvasive medical technique that has received
increasing attention over the last years and been applied for the treatment of certain types of …