Systemic lupus erythematosus (SLE) is characterized by high-titer serological
autoantibodies, including antibodies that bind to double-stranded DNA (dsDNA). The origin …

Genetic and environmental factors appear to contribute to the pathogenesis of systemic
lupus erythematosus (SLE). Viral infections have been reported to be associated with the …

The discovery of microRNA (miRNA) is one of the major scientific breakthroughs in recent
years and has revolutionized current cell biology and medical science. miRNAs are small …

There has been an explosion of literature focusing on the role of regulatory T (Treg) cells in
cancer immunity. It is becoming increasingly clear that Treg cells play an active and …

Abstract Programmed cell death 1 (PD-1) is an immunosuppressive receptor that transduces
an inhibitory signal into activated T cells. Although a single nucleotide polymorphism in the …

As a component of the innate immune cell population, γδ T cells are involved in tumor
immunosurveillance and host defense against viral invasion. In this study, we demonstrated …

Systemic lupus erythematosus (SLE) is a complex autoimmune disease. Approximately one‐
third to two‐thirds of the patients with SLE progress to lupus nephritis (LN). The …

Thymus-derived CD4+ CD25highFoxp3+ T-regulatory cells (Tregs) have an important role in
the mechanisms of peripheral immune tolerance and in the prevention of pathogenic …

Toll-like receptor (TLR) activation by pathogens can induce the activation of diverse cell
populations of the immune system and, therefore, can initiate or augment protective T-helper …

The invention is directed to T cell epitopes Wherein said epitopes comprises a peptide or
polypeptide chain compris ing at least a portion of an immunoglobulin constant or vari able …