The cancer microenvironment is known for its complexity, both in its content as well as its
dynamic nature, which is difficult to study using two-dimensional (2D) cell culture models …

The regulatory role of the immune system in maintaining bone homeostasis and restoring its
functionality, when disturbed due to trauma or injury, has become evident in recent years …

Long acting injectable formulations have been developed to sustain the action of drugs in
the body over desired periods of time. These delivery platforms have been utilized for both …

Scaffolds are an integral part of the regenerative medicine field. The contact of biomaterials
with tissue, as was clearly observed over the years, induces immune reactions in a material …

Macrophages are essential immune cells and play a major role in the immune response as
pro-inflammatory or anti-inflammatory agents depending on their plasticity and functions …

Scaffolds with multiple advantageous biological and structural properties are still a
challenge in the field of tissue engineering. The convergence of advanced fabrication …

Appropriate macrophage response to an implanted biomaterial is crucial for successful
tissue healing outcomes. In this work we investigated how intrinsic topological cues from …

Drug and chemical development along with safety tests rely on the use of numerous clinical
models. This is a lengthy process where animal testing is used as a standard for pre-clinical …

In situ tissue engineering that uses resorbable synthetic heart valve scaffolds is an
affordable and practical approach for heart valve replacement; therefore, it is attractive for …

Musculoskeletal disorders are common in clinical practice. Repairing critical-sized defects in
musculoskeletal systems remains a challenge for researchers and surgeons, requiring the …