A key goal to controlling coronavirus disease 2019 (COVID-19) is developing an effective
vaccine. Development of a vaccine requires knowledge of what constitutes a protective …

Proper development and function of the mammalian central nervous system (CNS) depend
critically on the activity of parenchymal sentinels referred to as microglia. Although microglia …

Although coronaviruses were first identified nearly 60 years ago, they only received notoriety
in 2003 when one of their members was identified as the aetiological agent of severe acute …

At the end of 2002, the first cases of severe acute respiratory syndrome (SARS) were
reported, and in the following year, SARS resulted in considerable mortality and morbidity …

A novel coronavirus (SARS-CoV-2) emerged from Wuhan, China, and spread quickly
around the world. In addition to fever, cough and shortness of breath, it was confirmed that …

The rapid spread of Coronavirus disease 2019 (COVID-19) caused by severe acute
respiratory syndrome coronavirus 2 has become a public health emergency of international …

ABSTRACT Unlike SARS-CoV-1 and MERS-CoV, infection with SARS-CoV-2, the viral
pathogen responsible for COVID-19, is often associated with neurologic symptoms that …

Intracranial (ic) inoculation of susceptible mice with a glial-tropic strain of mouse hepatitis
virus (JHMV), a murine coronavirus, results in an acute encephalomyelitis followed by viral …

Background Triggering receptor expressed on myeloid cells 2 (Trem2) plays a protective
role in neurodegenerative diseases. By contrast, Trem2 functions can exacerbate tissue …

Intracranial (ic) infection of susceptible C57BL/6 mice with the neurotropic JHM strain of
mouse hepatitis virus (JHMV)(a member of the Coronaviridae family) results in acute …