Human endogenous retroviruses role in cancer cell stemness

C Matteucci, E Balestrieri, A Argaw-Denboba… - Seminars in cancer …, 2018 - Elsevier
Cancer incidence and mortality, metastasis, drug resistance and recurrence are still the
critical issues of oncological diseases. In this scenario, increasing scientific evidences …

Transcriptional Landscape of Repetitive Elements in Psoriatic Skin from Large Cohort Studies: Relevance to Psoriasis Pathophysiology

VS Krishnan, S Kõks - International journal of molecular sciences, 2023 - mdpi.com
While studies demonstrating the expression of repetitive elements (REs) in psoriatic skin
using RNA-seq have been published before, not many studies have focused on the genome …

Discovery of natural bispecific antibodies: Is psoriasis induced by a toxigenic Corynebacterium simulans and maintained by CIDAMPs as autoantigens?

JM Schröder - Experimental Dermatology, 2024 - Wiley Online Library
The high abundance of Corynebacterium simulans in psoriasis skin suggests a contribution
to the psoriasis aetiology. This hypothesis was tested in an exploratory study, where western …

Causes of Autoimmune Psoriasis and Associated Cardiovascular Disease: Roles of Human Endogenous Retroviruses and Antihypertensive Drugs, A Systematic …

A Rezabakhsh, MH Manjili, H Hosseinifard… - medRxiv, 2023 - medrxiv.org
Current treatments are ineffective to cure or prevent occurrences of autoimmune psoriasis
and psoriatic cardiovascular disease/CVD. Psoriasis is associated with deregulated …

Expression quantitative trait loci (eQTLs) associated with retrotransposons demonstrate their modulatory effect on the transcriptome

S Koks, AL Pfaff, VJ Bubb, JP Quinn - International Journal of Molecular …, 2021 - mdpi.com
Transposable elements (TEs) are repetitive elements that belong to a variety of functional
classes and have an important role in shaping genome evolution. Around 50% of the human …

Human endogenous retroviruses in glioblastoma multiforme

Z Yuan, Y Yang, N Zhang, C Soto, X Jiang, Z An… - Microorganisms, 2021 - mdpi.com
Glioblastoma multiforme (GBM) is the most aggressive and deadly brain tumor. It is primarily
diagnosed in the elderly and has a 5-year survival rate of less than 6% even with the most …

HERV-K and HERV-W transcriptional activity in myalgic encephalomyelitis/chronic fatigue syndrome

LS Rodrigues, LH da Silva Nali, COD Leal… - Autoimmunity …, 2019 - Springer
Background Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/MS) is an
incapacitating chronic disease that dramatically compromise the life quality. The CFS/ME …

Analysis of repetitive element expression in the blood and skin of patients with Parkinson's disease identifies differential expression of satellite elements

KJ Billingsley, F Lättekivi, A Planken, E Reimann… - Scientific Reports, 2019 - nature.com
Repetitive elements (RE) constitute the majority of the human genome and have a range of
functions both structural and regulatory on genomic function and gene expression. RE …

The impact of wound-healing assay, phorbol myristate acetate (PMA) stimulation and siRNA-mediated FURIN gene silencing on endogenous retroviral ERVW-1 …

G Machnik, Ł Bułdak, K Zapletal-Pudełko… - Advances in Medical …, 2024 - Elsevier
Abstract Purpose Human endogenous retroviruses (HERVs) are ubiquitous genomic
sequences. Normally dormant HERVs, undergo reactivation by environmental factors. This …

A novel colony‐stimulating factor 1 (CSF1) translocation involving human endogenous retroviral element in a tenosynovial giant cell tumor

A Lipplaa, D Meijer, MAJ van de Sande… - Genes …, 2023 - Wiley Online Library
Tenosynovial giant cell tumors (TSGCTs) are rare tumors arising in tendons or the synoviae
of joints and bursae. The localized type is benign while the diffuse type shows expansive …