Obesity and ageing place a tremendous strain on the global healthcare system. Age-related
sarcopenia is characterized by decreased muscular strength, decreased muscle quantity …

Traditionally, peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α), a 91 kDa
transcription factor, regulates lipid metabolism and long-chain fatty acid oxidation by …

Physical exercise has beneficial effects on metabolic diseases, and a combined therapeutic
regimen of regular exercise and pharmaceutical treatment is often recommended for their …

Importance Antibody blockade of activin type II receptor (ActRII) signaling stimulates skeletal
muscle growth. Previous clinical studies suggest that ActRII inhibition with the monoclonal …

Exercise is an effective strategy for preventing and treating obesity and its related
cardiometabolic disorders, resulting in significant loss of body fat mass, white adipose tissue …

As age increases, the risk of developing type 2 diabetes increases, which is associated with
senile skeletal muscle dysfunction. During skeletal muscle aging, mitochondrial dysfunction …

Skeletal muscle is composed of a large and heterogeneous assortment of cell populations
that interact with each other to maintain muscle homeostasis and orchestrate regeneration …

During the past decade, skeletal muscle has been identified as a secretory organ.
Accordingly, we have suggested that cytokines and other peptides that are produced …

The concept of a “polypill” is receiving growing attention to prevent cardiovascular disease.
Yet similar if not overall higher benefits are achievable with regular exercise, a drug-free …

Exercise has beneficial effects in ameliorating metabolic disorders, and a combined
therapeutic regimen of regular exercise and pharmaceutical treatment is often …