[HTML][HTML] Treatment de-escalation for HPV-driven oropharyngeal cancer: where do we stand?

H Mirghani, P Blanchard - Clinical and translational radiation oncology, 2018 - Elsevier
HPV-driven oropharyngeal cancers have significantly better survival rates than tobacco and
alcohol induced head and neck cancers. As HPV-positive patients are younger, healthier …

Detection of transcriptionally active high-risk HPV in patients with head and neck squamous cell carcinoma as visualized by a novel E6/E7 mRNA in situ hybridization …

JA Bishop, XJ Ma, H Wang, Y Luo, PB Illei… - The American journal …, 2012 - journals.lww.com
Evidence for transcriptional activation of the viral oncoproteins E6 and E7 is regarded as the
gold standard for the presence of clinically relevant human papillomavirus (HPV), but …

Molecular pathology of head and neck cancer: implications for diagnosis, prognosis, and treatment

SI Pai, WH Westra - Annual Review of Pathology: Mechanisms …, 2009 - annualreviews.org
The prototypic head and neck squamous cell carcinoma (HNSCC) arises from the mucosal
lining of the upper aerodigestive tract, demonstrates squamous differentiation …

Comparison of human papillomavirus in situ hybridization and p16 immunohistochemistry in the detection of human papillomavirus‐associated head and neck cancer …

AD Singhi, WH Westra - Cancer, 2010 - Wiley Online Library
BACKGROUND: Human papillomavirus (HPV) is a causative agent in a subset of head and
neck squamous cell carcinomas (HNSCCs). These HPV‐related cancers have a …

The clinical impact of HPV tumor status upon head and neck squamous cell carcinomas

E Benson, R Li, D Eisele, C Fakhry - Oral oncology, 2014 - Elsevier
Human papillomavirus (HPV) is etiologically responsible for a distinct subset of head and
neck squamous cell cancers (HNSCCs). HPV-positive HNSCCs (HPV-HNSCCs) most …

The immune microenvironment of HPV-positive and HPV-negative oropharyngeal squamous cell carcinoma: A multiparametric quantitative and spatial analysis …

A Tosi, B Parisatto, A Menegaldo, G Spinato… - Journal of Experimental …, 2022 - Springer
Background Immune checkpoint inhibitors (ICI) are approved for treatment of recurrent or
metastatic oropharyngeal head and neck squamous cell carcinoma in the first-and second …

Human papillomavirus and diseases of the upper airway: head and neck cancer and respiratory papillomatosis

ML Gillison, L Alemany, PJF Snijders, A Chaturvedi… - Vaccine, 2012 - Elsevier
Human papillomavirus (HPV) infection is causally associated with benign and malignant
diseases of the upper airway, including respiratory papillomatosis and oropharyngeal …

p16 positive oropharyngeal squamous cell carcinoma: an entity with a favorable prognosis regardless of tumor HPV status

JS Lewis Jr, WL Thorstad, RD Chernock… - The American journal …, 2010 - journals.lww.com
Background In the human papillomavirus (HPV) era, the best way to assess oropharyngeal
squamous carcinomas (SCC) for risk stratification is not clear. Many recommend use of both …

Sexual behaviours and the risk of head and neck cancers: a pooled analysis in the International Head and Neck Cancer Epidemiology (INHANCE) consortium

JE Heck, J Berthiller, S Vaccarella… - International journal …, 2010 - academic.oup.com
Background Sexual contact may be the means by which head and neck cancer patients are
exposed to human papillomavirus (HPV). Methods We undertook a pooled analysis of four …

HPV prophylactic vaccines and the potential prevention of noncervical cancers in both men and women

ML Gillison, AK Chaturvedi, DR Lowy - Cancer, 2008 - Wiley Online Library
Human papillomavirus (HPV) is a necessary cause of cervical cancer. In addition, on the
basis of the fulfillment of a combination of viral as well as epidemiological criteria, it is …