Cancer epigenetics in clinical practice
V Davalos, M Esteller - CA: a cancer journal for clinicians, 2023 - Wiley Online Library
Cancer development is driven by the accumulation of alterations affecting the structure and
function of the genome. Whereas genetic changes disrupt the DNA sequence, epigenetic …
function of the genome. Whereas genetic changes disrupt the DNA sequence, epigenetic …
[HTML][HTML] New genetic and epigenetic insights into the chemokine system: The latest discoveries aiding progression toward precision medicine
H Xu, S Lin, Z Zhou, D Li, X Zhang, M Yu… - Cellular & Molecular …, 2023 - nature.com
Over the past thirty years, the importance of chemokines and their seven-transmembrane G
protein-coupled receptors (GPCRs) has been increasingly recognized. Chemokine …
protein-coupled receptors (GPCRs) has been increasingly recognized. Chemokine …
Multiplex epigenome editing of MECP2 to rescue Rett syndrome neurons
Rett syndrome (RTT) is an X-linked neurodevelopmental disorder caused by loss-of-function
heterozygous mutations of methyl CpG-binding protein 2 (MECP2) on the X chromosome in …
heterozygous mutations of methyl CpG-binding protein 2 (MECP2) on the X chromosome in …
Base editor scanning charts the DNMT3A activity landscape
DNA methylation is critical for regulating gene expression, necessitating its accurate
placement by enzymes such as the DNA methyltransferase DNMT3A. Dysregulation of this …
placement by enzymes such as the DNA methyltransferase DNMT3A. Dysregulation of this …
[HTML][HTML] Signaling pathways and targeted therapies for psoriasis
J Guo, H Zhang, W Lin, L Lu, J Su… - Signal Transduction and …, 2023 - nature.com
Psoriasis is a common, chronic, and inflammatory skin disease with a high burden on
individuals, health systems, and society worldwide. With the immunological pathologies and …
individuals, health systems, and society worldwide. With the immunological pathologies and …
[HTML][HTML] Dynamic antagonism between key repressive pathways maintains the placental epigenome
DNA and Histone 3 Lysine 27 methylation typically function as repressive modifications and
operate within distinct genomic compartments. In mammals, the majority of the genome is …
operate within distinct genomic compartments. In mammals, the majority of the genome is …
[HTML][HTML] Culture expansion of CAR T cells results in aberrant DNA methylation that is associated with adverse clinical outcome
Chimeric antigen receptor (CAR) T cells provide new perspectives for treatment of
hematological malignancies. Manufacturing of these cellular products includes culture …
hematological malignancies. Manufacturing of these cellular products includes culture …
[HTML][HTML] QTL mapping of human retina DNA methylation identifies 87 gene-epigenome interactions in age-related macular degeneration
DNA methylation provides a crucial epigenetic mark linking genetic variations to
environmental influence. We have analyzed array-based DNA methylation profiles of 160 …
environmental influence. We have analyzed array-based DNA methylation profiles of 160 …
[HTML][HTML] Molecular mechanisms underlying pluripotency and self-renewal of embryonic stem cells
Embryonic stem cells (ESCs) are derived from the inner cell mass (ICM) of the blastocyst.
ESCs have two distinctive properties: ability to proliferate indefinitely, a feature referred as …
ESCs have two distinctive properties: ability to proliferate indefinitely, a feature referred as …
[HTML][HTML] The Role of Hydrogen Sulfide (H2S) in Epigenetic Regulation of Neurodegenerative Diseases: A Systematic Review
BG Dogaru, C Munteanu - International Journal of Molecular Sciences, 2023 - mdpi.com
This review explores the emerging role of hydrogen sulfide (H2S) in modulating epigenetic
mechanisms involved in neurodegenerative diseases. Accumulating evidence has begun to …
mechanisms involved in neurodegenerative diseases. Accumulating evidence has begun to …