Local mutation rates in human are highly heterogeneous, with known variability at the scale
of megabase-sized chromosomal domains, and, on the other extreme, at the scale of …

As an important epigenetic regulator, histone lysine specific demethylase 1 (LSD1) has
become an attractive target for the discovery of anticancer agents. In this work, a series of …

Up till the present moment, breast cancer is still the leading cause of cancer-related death in
women worldwide. Although the treatment methods and protocols for breast cancer are …

Abstract Poly (ADP-ribosylation)(PARylation) is a post-translational modification mediated
by a subset of ADP-ribosyl transferases (ARTs). Although PARylation-inhibition based …

Simple Summary Hundreds of millions of patients of all ages undergo general anesthesia for
surgery or periods of sedation each year, making the adverse effects of general anesthesia …

Gut phages have an important impact on human health. Methylation plays key roles in DNA
recognition, gene expression regulation and replication for phages. However, the DNA …

Aquaculture assumes a pivotal role in meeting the escalating global food demand, and
shrimp farming, in particular, holds a significant role in the global economy and food …

Sequence-dependent DNA shape plays an important role in understanding protein–DNA
binding mechanisms. High-throughput prediction of DNA shape features has become a …

Aim Gestational diabetes mellitus (GDM) affects a significant number of women worldwide
and has been associated with lifelong health consequences for their offspring, including …

Embryonic neurodevelopment, particularly neural progenitor differentiation into post-mitotic
neurons, has been extensively studied. While the number and composition of post-mitotic …