Liver transplantation for hepatocellular carcinoma (HCC) is the best treatment option for
patients with early-stage tumours and accounts for∼ 20–40% of all liver transplantations …

Organ transplantation is undergoing profound changes. Contraindications for donation have
been revised in order to better meet the organ demand. The use of lower-quality organs and …

Liver transplantation is a highly successful treatment, but is severely limited by the shortage
in donor organs. However, many potential donor organs cannot be used; this is because sub …

Normothermic machine perfusion (NMP) has emerged as an innovative organ preservation
technique. Developing an understanding for the donor organ immune cell composition and …

Normothermic ex situ liver perfusion might allow viability assessment of livers before
transplantation. Perfusion characteristics were studied in 47 liver perfusions, of which 22 …

Background & Aims Donation after circulatory death (DCD) liver transplantation is known for
potentially worse outcomes because of higher rates of graft non-function or irreversible …

Background & Aims Although there is increasing interest in its use, definitive evidence
demonstrating a benefit for postmortem normothermic regional perfusion (NRP) in controlled …

The demand for liver transplantation (LT) exceeds supply, with rising waiting list mortality.
Utilization of high‐risk organs is low and a substantial number of procured livers are …

Organoid technology holds great promise for regenerative medicine but has not yet been
applied to humans. We address this challenge using cholangiocyte organoids in the context …

Background & Aims Primary non-function and ischaemic cholangiopathy are the most feared
complications following donation-after-circulatory-death (DCD) liver transplantation. The aim …