[HTML][HTML] Therapeutic peptides: current applications and future directions
L Wang, N Wang, W Zhang, X Cheng, Z Yan… - … and Targeted Therapy, 2022 - nature.com
Peptide drug development has made great progress in the last decade thanks to new
production, modification, and analytic technologies. Peptides have been produced and …
production, modification, and analytic technologies. Peptides have been produced and …
CGRP physiology, pharmacology, and therapeutic targets: migraine and beyond
Calcitonin gene-related peptide (CGRP) is a neuropeptide with diverse physiological
functions. Its two isoforms (α and β) are widely expressed throughout the body in sensory …
functions. Its two isoforms (α and β) are widely expressed throughout the body in sensory …
[HTML][HTML] The microbiota-gut-brain axis
I. INTRODUCTION 1877 II. STUDYING THE... 1881 III. MICROBIOTA-GUT-BRAIN AXIS...
1907 IV. PATHWAYS OF COMMUNICATION 1911 V. MICROBIOTA AND SYNAPTIC... 1929 …
1907 IV. PATHWAYS OF COMMUNICATION 1911 V. MICROBIOTA AND SYNAPTIC... 1929 …
Neuropathic pain: from mechanisms to treatment
Neuropathic pain caused by a lesion or disease of the somatosensory nervous system is a
common chronic pain condition with major impact on quality of life. Examples include …
common chronic pain condition with major impact on quality of life. Examples include …
[HTML][HTML] Bone marrow mesenchymal stem cell-derived exosomes protect cartilage damage and relieve knee osteoarthritis pain in a rat model of osteoarthritis
L He, T He, J Xing, Q Zhou, L Fan, C Liu… - Stem cell research & …, 2020 - Springer
Background This study aimed to investigate the effect of bone marrow mesenchymal stem
cell (BMSC)-derived exosome injection on cartilage damage and pain relief in both in vitro …
cell (BMSC)-derived exosome injection on cartilage damage and pain relief in both in vitro …
CGRP and the trigeminal system in migraine
S Iyengar, KW Johnson, MH Ossipov… - … : The Journal of Head …, 2019 - Wiley Online Library
Objective The goal of this narrative review is to provide an overview of migraine
pathophysiology, with an emphasis on the role of calcitonin gene‐related peptide (CGRP) …
pathophysiology, with an emphasis on the role of calcitonin gene‐related peptide (CGRP) …
Efficacy and safety of galcanezumab for the prevention of episodic migraine: results of the EVOLVE-2 phase 3 randomized controlled clinical trial
V Skljarevski, M Matharu, BA Millen… - …, 2018 - journals.sagepub.com
Introduction Galcanezumab is a humanized monoclonal antibody binding calcitonin gene-
related peptide, used for migraine prevention. Methods A global, double-blind, 6-month …
related peptide, used for migraine prevention. Methods A global, double-blind, 6-month …
A phase‐by‐phase review of migraine pathophysiology
DW Dodick - Headache: the journal of head and face pain, 2018 - Wiley Online Library
Migraine is a common, disabling neurological disorder characterized by multiple phases:
premonitory, aura, headache, postdrome, and interictal. Our understanding of the …
premonitory, aura, headache, postdrome, and interictal. Our understanding of the …
[HTML][HTML] Pain in endometriosis
Endometriosis is a chronic and debilitating condition affecting∼ 10% of women.
Endometriosis is characterized by infertility and chronic pelvic pain, yet treatment options …
Endometriosis is characterized by infertility and chronic pelvic pain, yet treatment options …
[HTML][HTML] Applying a biopsychosocial model to migraine: rationale and clinical implications
C Rosignoli, R Ornello, A Onofri, V Caponnetto… - The journal of headache …, 2022 - Springer
Migraine is a complex condition in which genetic predisposition interacts with other
biological and environmental factors determining its course. A hyperresponsive brain cortex …
biological and environmental factors determining its course. A hyperresponsive brain cortex …