Cytochrome P450 3A: ontogeny and drug disposition
The maturation of organ systems during fetal life and childhood exerts a profound effect on
drug disposition. The maturation of drug-metabolising enzymes is probably the predominant …
drug disposition. The maturation of drug-metabolising enzymes is probably the predominant …
Intravenous midazolam infusion for sedation of infants in the neonatal intensive care unit
E Ng, A Taddio - Cochrane Database of Systematic Reviews, 2017 - cochranelibrary.com
Background Proper sedation for neonates undergoing uncomfortable procedures may
reduce stress and avoid complications. Midazolam is a short‐acting benzodiazepine that is …
reduce stress and avoid complications. Midazolam is a short‐acting benzodiazepine that is …
Summary proceedings from the neonatal pain-control group
KJS Anand, JV Aranda, CB Berde, SA Buckman… - …, 2006 - publications.aap.org
Recent advances in neurobiology and clinical medicine have established that the fetus and
newborn may experience acute, established, and chronic pain. They respond to such …
newborn may experience acute, established, and chronic pain. They respond to such …
Premedication for nonemergency endotracheal intubation in the neonate.
P Kumar, SE Denson, TJ Mancuso - Pediatrics, 2010 - europepmc.org
Endotracheal intubation is a common procedure in newborn care. The purpose of this
clinical report is to review currently available evidence on use of premedication for …
clinical report is to review currently available evidence on use of premedication for …
Scaling clearance in paediatric pharmacokinetics: all models are wrong, which are useful?
E Germovsek, CIS Barker, M Sharland… - British journal of …, 2017 - Wiley Online Library
Linked Articles This article is commented on in the editorial by Holford NHG and Anderson
BJ. Why standards are useful for predicting doses. Br J Clin Pharmacol 2017; 83: 685–7. doi …
BJ. Why standards are useful for predicting doses. Br J Clin Pharmacol 2017; 83: 685–7. doi …
Facilitation of drug evaluation in children by population methods and modelling
M Tod, V Jullien, G Pons - Clinical pharmacokinetics, 2008 - Springer
The pharmacokinetics and pharmacodynamics of drugs are different in adult and paediatric
populations, the latter being particularly heterogeneous. These differences in …
populations, the latter being particularly heterogeneous. These differences in …
Ontogeny of hepatic and renal systemic clearance pathways in infants: part II
J Alcorn, PJ McNamara - Clinical pharmacokinetics, 2002 - Springer
Maturation of drug systemic clearance mechanisms during the postnatal period produces
dramatic and rapid changes in an infant's capacity to eliminate drugs. A tentative general …
dramatic and rapid changes in an infant's capacity to eliminate drugs. A tentative general …
Analgesia and local anesthesia during invasive procedures in the neonate
BACKGROUND:: Preterm and full-term neonates admitted to the neonatal intensive care unit
or elsewhere in the hospital are routinely subjected to invasive procedures that can cause …
or elsewhere in the hospital are routinely subjected to invasive procedures that can cause …
Analgesia and sedation during mechanical ventilation in neonates
BACKGROUND:: Endotracheal intubation and mechanical ventilation are major components
of routine intensive care for very low birth weight newborns and sick full-term newborns …
of routine intensive care for very low birth weight newborns and sick full-term newborns …
Population pharmacokinetics and metabolism of midazolam in pediatric intensive care patients
SN De Wildt, M De Hoog, AA Vinks… - Critical care …, 2003 - journals.lww.com
Interventions The pharmacokinetics of midazolam and metabolites were determined during
and after a continuous infusion of midazolam (0.05–0.4 mg/kg/hr) for 3.8 hrs to 25 days …
and after a continuous infusion of midazolam (0.05–0.4 mg/kg/hr) for 3.8 hrs to 25 days …