Microbial resistance is a serious threat to human health worldwide. Among the World Health
Organisation's list of priority resistant bacteria, three are listed as critical—the highest level of …

Background Patients with bacteremia due to carbapenem-resistant Enterobacterales (CRE)
experience delays until appropriate therapy and high mortality rates. Rapid molecular …

Background Nephrotoxicity and neurotoxicity are commonly associated with polymyxin
treatment; however, the emergence of multidrug-resistant Gram-negative bacteria with …

Carbapenem-resistant Enterobacterales (CRE) are a growing threat to human health
worldwide. CRE often carry multiple resistance genes that limit treatment options and …

Imipenem/cilastatin/relebactam (Recarbrio™) is an intravenously administered combination
of the carbapenem imipenem, the renal dehydropeptidase-I inhibitor cilastatin, and the novel …

Antimicrobial drug resistance is one of the major threats to global health. It has made
common infections increasingly difficult or impossible to treat, and leads to higher medical …

The spread of antibiotic-resistant bacteria poses a substantial threat to morbidity and
mortality worldwide. Carbapenem-resistant Pseudomonas aeruginosa (CRPA) are …

Carbapenem-resistant Enterobacterales (CRE) remain a significant public health threat,
and, despite recent approvals, new antibiotics are needed. Severe infections caused by …

Hospital-acquired pneumonia (HAP) and ventilator-associated pneumonia (VAP) represent
one of the most common hospital-acquired infections, carrying a significant morbidity and …

Infants admitted to the neonatal intensive care unit, particularly those born preterm, are at
high risk for infection due to the combination of an immature immune system, prolonged …