Many drug molecules that are currently in the market suffer from short half-life, poor
absorption, low specificity, rapid degradation, and resistance development. The design and …

Injectable in situ forming hydrogels are amongst the efficient local drug delivery systems for
cancer therapy. Providing a 3D hydrogel network within the target tissue capable of …

Hydrogels have been extensively investigated as biomaterials because of their excellent
biocompatibility, and recent developments such as 3D printing and the incorporation of …

Post-operative recurrence and metastasis is a major challenge for breast cancer treatment.
Local chemotherapy is a promising strategy that can overcome this problem. In this study …

Gemcitabine (Gem), an analogue of deoxycytidine, has potent antitumor activities against
various solid tumors and is an excellent radiosensitizer as well. However, Gem has a very …

Background Glioblastoma (GBM) is the most common and aggressive primary brain tumor in
adults. Despite the gold standard treatment combining surgical resection, radiation and …

Despite the emergence of cutting-edge therapeutic strategies and tremendous progress in
research, a complete cure of glioma remains elusive. The heterogenous nature of tumor …

Nanocarrier administration has primarily been restricted to intermittent bolus injections with
limited available options for sustained delivery in vivo. Here, we demonstrate that cylinder-to …

In spite of substantial progress made in the standard treatment and ancillary therapies that
include concurrent chemotherapy, radiotherapy, and surgery, malignant brain tumors …

Regulation of cell behaviors and even cell fates is of great significance in diverse biomedical
applications such as cancer treatment, cell-based therapy, and tissue engineering. During …