Bioinspired tissue-compliant hydrogels with multifunctions for synergistic surgery–photothermal therapy

W Jiang, Y Chen, L Zhao, J Xu, R Zhao… - Journal of Materials …, 2020 - pubs.rsc.org
Operation therapy is a common treatment for many cancers, but malignant tumors likely
recur and metastasize after surgery, resulting in treatment failure. In this study, we aimed at …

Chlorogenic acid sustained-release gel for treatment of glioma and hepatocellular carcinoma

H Zhou, D Chen, T Gong, Q He, C Guo, P Zhang… - European Journal of …, 2021 - Elsevier
Chlorogenic acid (CGA) may provide an effective and safe option for tumor treatment.
However, its application is limited because of short residence time in vivo and repeated …

Poly (l-glutamic acid)-g-methoxy poly (ethylene glycol)-gemcitabine conjugate improves the anticancer efficacy of gemcitabine

C Yang, W Song, D Zhang, H Yu, L Yin, N Shen… - International Journal of …, 2018 - Elsevier
Gemcitabine is widely used for anticancer therapy. However, its short blood circulation time
and poor stability greatly impair its application. To solve this problem, we prepared a poly (l …

Brain tumor vessels—a barrier for drug delivery

C Hempel, KB Johnsen, S Kostrikov, P Hamerlik… - Cancer and Metastasis …, 2020 - Springer
Cancer treatment remains a challenge due to a high level of intra-and intertumoral
heterogeneity and the rapid development of chemoresistance. In the brain, this is further …

Bioscaffold-based study of glioblastoma cell behavior and drug delivery for tumor therapy

K Tran, R Brice, L Yao - Neurochemistry International, 2021 - Elsevier
Glioblastoma multiforme (GBM) is a severe form of brain cancer with an average five-year
survival rate of 6.7%. Current treatment strategies include surgical resection of the tumor …

Hydrogel-based drug delivery systems for cancer therapy

B Mishra, J Singh - Advanced drug delivery systems in the management of …, 2021 - Elsevier
Hydrogels have been employed for applications like wounds, burns, dressings, contact
lenses, tissue engineering applications, to name a few. The potential of hydrogel application …

Matrix metalloproteinase responsive hydrogel microplates for programmed killing of invasive tumour cells

AB Cook, A Palange, M Schlich, E Bellotti… - RSC Applied …, 2023 - pubs.rsc.org
Interactive materials are an emerging class of systems that can offer control over response
and adaptivity in polymer structures towards the meso-and macroscale. Here, we use …

Perspective on Translating Biomaterials Into Glioma Therapy: Lessons From in Vitro Models

RC Cornelison, JM Munson - Frontiers in materials, 2018 - frontiersin.org
Glioblastoma (GBM) is the most common and malignant form of brain cancer. Even with
aggressive standard of care, GBM almost always recurs because its diffuse, infiltrative …

Detection of Label-Free Drugs within Brain Tissue Using Orbitrap Secondary Ion Mass Spectrometry as a Complement to Neuro-Oncological Drug Delivery

P McCrorie, J Rowlinson, DJ Scurr, M Marlow… - Pharmaceutics, 2022 - mdpi.com
Historically, pre-clinical neuro-oncological drug delivery studies have exhaustively relied
upon overall animal survival as an exclusive measure of efficacy. However, with no adopted …

An Extensive Review on Hydrogels in Pharmaceutical Drug Delivery Applications.

S Rajaram, SR Dharmalingam… - International …, 2022 - search.ebscohost.com
In recent years pharmaceutical companies are directing towards designing new
pharmaceutical dosage forms of existing medications. Recent breakthroughs have been the …