Rheumatoid arthritis is a common inflammatory disease with complex genetic components.
We investigated the genetic contribution of the cytokine gene cluster in chromosome 5q31 to …

The genome-wide association study is a free-hypothesis approach based on screening of
thousands or even millions of genetic variants distributed throughout the whole human …

The past year has seen significant advances in our understanding of the critical roles of
negative immunoregulatory signals delivered by the programmed death 1 (PD-1)–PD-1 …

Maintenance of peripheral tolerance is essential for homeostasis of the immune system.
While central tolerance mechanisms result in deletion of the majority of self-reactive T cells …

Genetic variation was first shown to be important in systemic lupus erythematosus (SLE or
lupus) in the 1970s with associations in the human leukocyte antigen region. Almost four …

The programmed cell death protein 1 (PD-1) is expressed by activated T cells that act as an
immunoregulatory molecule, and are responsible for the negative regulation of T cell …

B7-H1 is a recently identified member of the B7 family molecules. Upon ligation to its
receptors on T cells it regulates activation and differentiation of T cells. B7-H1 preferentially …

Objective To determine whether there is familial aggregation of systemic lupus
erythematosus (SLE) and/or other autoimmune diseases in SLE patients and to identify …

TREX1, originally designated DNase III, was isolated as a major nuclear DNA-specific 3′→
5′ exonuclease that is widely distributed in both proliferating and nonproliferating …

Antibodies that block the immune checkpoint receptors PD1 and CTLA4 have revolutionized
the treatment of melanoma and several other cancers, but in the process, a new class of …