Head and neck cancer (HNC) is malignant, genetically complex and difficult to treat and is
the sixth most frequent cancer, with tobacco, alcohol and human papillomavirus being major …

Head and neck squamous cell carcinoma (HNSCC) is the sixth most common non-skin
cancer with a tobacco consumption and infection with high-risk human papillomavirus (HPV) …

Simple Summary This review provides an overview of the state of knowledge and general
understanding of CDK inhibitors currently under development or clinically approved, with a …

Head and neck cancer (HNC) is a term collectively used to describe a heterogeneous group
of tumors that arise in the oral cavity, larynx, nasopharynx, oropharynx, and hypopharynx …

Oral cancer is a highly aggressive tumor with invasive properties that can lead to metastasis
and high mortality rates. Conventional treatment strategies, such as surgery, chemotherapy …

Cyclin-dependent kinases (CDK) control the cell cycle and play a crucial role in
oncogenesis. Pharmacologic inhibition of CDK has contributed to the recent clinical …

Regulated cell division is one of the fundamental phenomena which is the basis of all life on
earth. Even a single base pair mutation in DNA leads to the production of the dysregulated …

Sepsis in the young population, which is particularly at risk, is rarely studied. O-
GlcNAcylation is a post-translational modification involved in cell survival, stress response …

Aim Metabolic sources switch from carbohydrates in utero, to fatty acids after birth and then a
mix once adults. O‐GlcNAcylation (O‐GlcNAc) is a post‐translational modification …

Objectives We previously reported that palbociclib, a selective CDK4/6 inhibitor, given with
cetuximab, resulted in an objective response rate (ORR) of 19% in cetuximab-resistant …