NMDA receptor activation-dependent antidepressant-relevant behavioral and synaptic actions of ketamine
Ketamine is a well-characterized NMDA receptor (NMDAR) antagonist, although the
relevance of this pharmacology to its rapid (within hours of administration) antidepressant …
relevance of this pharmacology to its rapid (within hours of administration) antidepressant …
Antidepressant actions of ketamine engage cell-specific translation via eIF4E
Effective pharmacotherapy for major depressive disorder remains a major challenge, as
more than 30% of patients are resistant to the first line of treatment (selective serotonin …
more than 30% of patients are resistant to the first line of treatment (selective serotonin …
Reproducing the dopamine pathophysiology of schizophrenia and approaches to ameliorate it: a translational imaging study with ketamine
M Kokkinou, EE Irvine, DR Bonsall, S Natesan… - Molecular …, 2021 - nature.com
Patients with schizophrenia show increased striatal dopamine synthesis capacity in imaging
studies. The mechanism underlying this is unclear but may be due to N-methyl-D-aspartate …
studies. The mechanism underlying this is unclear but may be due to N-methyl-D-aspartate …
Investigation of the underling mechanism of ketamine for antidepressant effects in treatment‑refractory affective disorders via molecular profile analysis
J Qiao, Y Sun, J Wu, L Wang - Experimental and …, 2019 - spandidos-publications.com
Ketamine elicits a rapid antidepressant effect in treatment‑refractory affective disorders. The
aim of the present study was to elucidate the underlying mechanism of this effect and to …
aim of the present study was to elucidate the underlying mechanism of this effect and to …