Ras homolog gene family member A (RhoA) is a small GTPase of the Rho family involved in
regulating multiple signal transduction pathways that influence a diverse range of cellular …

The clinical correlations linking diabetes mellitus with accelerated atherosclerosis,
cardiomyopathy, and increased post-myocardial infarction fatality rates are increasingly …

Reactive oxygen species (ROS) are key signaling molecules that play an important role in
the progression of inflammatory disorders. An enhanced ROS generation by …

Transforming growth factor beta (TGF-β) is the most potent pro-fibrogenic cytokine and its
expression is increased in almost all of fibrotic diseases. Although signaling through Smad …

Oxidative stress has long been implicated in cardiovascular disease, but more recently, the
role of reactive oxygen species (ROS) in normal physiological signaling has been …

The brain is one of the most exquisite organs in the body with high metabolic demands, and
requires a tight regulation of the surrounding environment. This tight control is exerted by the …

Wound healing is an essential biological process that comprises sequential steps aimed at
restoring the architecture and function of damaged cells and tissues. This process begins …

Many fundamental processes in cell biology are regulated by Rho GTPases, including cell
adhesion, migration and differentiation. While regulating cellular functions, members of the …

Spatiotemporal regulation of the activity of a vast array of intracellular proteins and signaling
pathways by reactive oxygen species (ROS) governs normal cardiovascular function …

The last 20–25 years have seen an explosion of interest in the role of NADPH oxidase
(NOX) in cardiovascular function and disease. In vascular smooth muscle and endothelium …