Multiple sclerosis (MS) is a chronic inflammatory and degenerative disease of the central
nervous system afflicting nearly three million individuals worldwide. Neuroimmune …

Chronic inflammation is the main feature of many long-term inflammatory diseases such as
autoimmune diseases, metabolic disorders, and cancer. There is a growing number of …

Recent studies have begun to reveal critical roles for the brain's professional phagocytes,
microglia, and their receptors in the control of neurotoxic amyloid beta (Aβ) and myelin …

Myeloid-derived suppressor cells (MDSCs) are innate immune cells that acquire the
capacity to suppress adaptive immune responses during cancer. It remains elusive how …

Neutrophil recruitment is not only vital for host defense, but also relevant in pathological
inflammatory reactions, such as sepsis. Model systems have been established to examine …

Matrix mechanics regulate essential cell behaviors through mechanotransduction, and as
one of its most important elements, substrate stiffness was reported to regulate cell functions …

Abstract Anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis is a neuropsychiatric
disease characterized by an antibody-mediated autoimmune response against NMDAR …

Pathologic roles of innate immunity in neurologic disorders are well described, but their
beneficial aspects are less understood. Dectin-1, a C-type lectin receptor (CLR), is largely …

Multiple sclerosis (MS) is a demyelinating disease of the central nervous system with a
strong autoimmune, neurodegenerative, and neuroinflammatory component. Most of the …

Colorectal cancer is multifaceted, with subtypes defined by genetic, histologic, and
immunologic features that are potentially influenced by inflammation, mutagens, and/or …