A high caloric intake, rich in saturated fats, greatly contributes to the development of obesity,
which is the leading risk factor for type 2 diabetes (T2D). A persistent caloric surplus …

Pancreatic β-cell failure and death contribute significantly to the pathogenesis of type 2
diabetes. One of the main factors responsible for β-cell dysfunction and subsequent cell …

Obesity is a recognized epidemic worldwide, and the accumulation of excess free saturated
fatty acids (SFAs) in cells induces cellular lipotoxic damage and increases the risk of a wide …

There are strong links between obesity, elevated free fatty acids, and type 2 diabetes.
Specifically, the saturated fatty acid palmitate has pleiotropic effects on β-cell function and …

Lipotoxicity has been considered a major cause for beta-cell dysfunction in type 2 diabetes
mellitus. However, the underlying mechanisms are still unclear. To achieve a better …

Aims/hypothesis Non-alcoholic fatty liver disease (NAFLD) is associated with insulin
resistance and characterised by different degrees of hepatic lesion. Its pathogenesis and …

It is widely accepted that, in type 2 diabetes, elevated levels of free fatty acids and glucose
contribute to a state of glucolipotoxicity in which β-cell function declines and, ultimately, cell …

Aims: In this study we have tested the effect of unsaturated fatty acids on the proapoptotic
effects of saturated fatty acids in the human pancreatic β-cells NES2Y. Results: We found …

Pancreatic β-cell failure and death is considered to be one of the main factors responsible
for type 2 diabetes. It is caused by, in addition to hyperglycemia, chronic exposure to …

Despite the growing interest in deciphering the causes and consequences of obesity-related
disorders, the mechanisms linking fat intake to bone behaviour remain unclear. Since bone …