Vitamin B12 (cobalamin, Cbl, B12) is an indispensable water-soluble micronutrient that
serves as a coenzyme for cytosolic methionine synthase (MS) and mitochondrial …

Abstract Vitamin B12 (B12; also known as cobalamin) is a cofactor in many metabolic
processes; deficiency of this vitamin is associated with megaloblastic anaemia and various …

Summary of key recommendations The clinical picture is the most important factor in
assessing the significance of test results assessing cobalamin status because there is no …

Derivatives of cobalamin (vitamin B12) are required for activity of two enzymes in humans.
Adenosylcobalamin is required for activity of mitochondrial methylmalonylCoA mutase and …

Vitamin B12 is critical for hematopoiesis and myelination. Deficiency can cause neurologic
deficits including loss of coordination and cognitive decline. However, diagnosis relies on …

Nutritional and genetic deficiencies of folate and vitamin B 12 lead to elevation of cellular
homocysteine (Hcy), which translates in increased plasma Hcy. The sources and role of …

Vitamin B12 (cobalamin, Cbl) is an essential nutrient in human metabolism. Genetic
diseases of vitamin B12 utilisation constitute an important fraction of inherited newborn …

For this GeneReview, the term" isolated methylmalonic acidemia" refers to a group of inborn
errors of metabolism associated with elevated methylmalonic acid (MMA) concentration in …

This review gives an overview of clinical characteristics, treatment and outcome of nutritional
and acquired cobalamin (Cbl; synonym: vitamin B12) deficiencies, inborn errors of Cbl …

Vitamin B-12 is a water-soluble vitamin that plays important roles in intermediary
metabolism. Vitamin B-12 deficiency has many identifiable causes, including autoimmune …