Recent studies have added substantially to our knowledge of spatial and temporal trends of
persistent organic pollutants and heavy metals in the Canadian Arctic marine ecosystem …

A genotoxin is a chemical or agent that can cause DNA or chromosomal damage. Such
damage in a germ cell has the potential to cause a heritable altered trait (germline mutation) …

The methodology applied for DNA adducts in humans has become more reliable in recent
years, allowing to detect even background carcinogenic adduct levels in environmentally …

DNA adducts have been investigated extensively during the past decade. This research has
been advanced, in part, by the development of ultrasensitive analytical methods, such as …

The carcinogens to which humans are exposed are normally in the form of complex
mixtures, and much effort has gone into determining the nature of the most significant …

The use of mercapturic acids (N-acetyl-L-cysteine S-conjugates, MAs) in the biological
monitoring of human exposure to environmental and industrial chemicals is receiving more …

Epidemiologic studies indicate that prolonged exposure to high pollution levels is
associated with increased risk of cancer, especially lung cancer. However, under conditions …

It is undisputed that DNA adduct formation is one of the key processes in early
carcinogenesis. Therefore, analysis of DNA adduct levels may be one of the best tools …

Direct epidemiological observations suggest that exposure to high levels of urban air
pollution may result in increased risk of lung cancer, sufficient to account for a few (∼ 1–3) …

Metabolic polymorphisms have long been recognized as important determinants of
carcinogen susceptibility and recent efforts have shown that interindividual differences in …