Abstract Growth differentiation factor 15 (GDF15), a member of the transforming growth
factor-beta superfamily, is expressed in several human organs. In particular, it is highly …

Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive scarring interstitial lung disease
with an unknown cause. Some patients may experience acute exacerbations (AE), which …

Exercise is a first-line treatment for type 2 diabetes and preserves β-cell function by hitherto
unknown mechanisms. We postulated that proteins from contracting skeletal muscle may act …

Oxidative stress is a predisposing factor in Chronic Obstructive Pulmonary Disease (COPD).
Specifically, pulmonary epithelial (PE) cells reduce antioxidant capacity during COPD …

Background Idiopathic pulmonary fibrosis (IPF) is a rare interstitial lung disease with a poor
prognosis that currently lacks effective treatment methods. Preventing the acute …

Pluripotency can be induced in somatic cells by the expression of the four “Yamanaka”
factors OCT4, KLF4, SOX2, and MYC. However, even in homogeneous conditions, usually …

The extracellular matrix (ECM) is a complex assembly of proteins that provide interstitial
scaffolding and elastic recoil for human lungs. The pulmonary extracellular matrix is …

Pluripotency can be induced in somatic cells by the expression of OCT4, KLF4, SOX2, and
MYC. Usually only a rare subset of cells reprogram, and the molecular characteristics of this …

Introduction Growth Differentiation Factor 15 (GDF15) is a mitokine expressed in response to
various stresses whose circulating levels increase with age and are associated with …

Background and purpose Radiomics is a rapidly evolving area of research that uses medical
images to develop prognostic and predictive imaging biomarkers. In this study, we aimed to …