Ferroptosis is a newly recognized form of oxidative-regulated cell death resulting from iron-
mediated lipid peroxidation accumulation. Radical-trapping antioxidant systems can …

Mitochondria are complex organelles that orchestrate several functions in the cell. The
primary function recognized is energy production; however, other functions involve the …

The effects of environmental factors and epigenetics on health and disease development
are complex and interconnected. Environmental factors encompass external influences like …

Abstract Objectives Systemic sclerosis (SSc) is associated with secondary malignancies.
Previous studies have suggested that mutated cancer proteins, such as RNA polymerase III …

RNA modification plays an important role in epigenetics at the posttranscriptional level, and
5-methylcytosine (m5C) has attracted increasing attention in recent years due to the …

Abstract Background Myelodysplastic Neoplasms (MDS) are clonal stem cell disorders
characterized by ineffective hematopoiesis and progression to acute myeloid leukemia …

Obesity is a complex metabolic disorder, manifesting as excessive accumulation of body fat.
Ten-Eleven Translocation-2 (TET2) has garnered significant attention in the context of …

Decrease in DNA dioxygenase activity generated by TET2 gene family is crucial in
myelodysplastic syndromes (MDS). The general downregulation of 5-hydroxymethylcytosine …

Drug resistance (DR) of cancer cells leading to relapse is a huge problem nowadays to
achieve long-lasting cures for cancer patients. This also holds true for the incurable …

Aberrant DNA hypermethylation at regulatory cis-elements of particular genes is seen in a
plethora of pathological conditions including cardiovascular, neurological, immunological …