New developments in the biology of fibroblast growth factors

DM Ornitz, N Itoh - WIREs mechanisms of disease, 2022 - Wiley Online Library
The fibroblast growth factor (FGF) family is composed of 18 secreted signaling proteins
consisting of canonical FGFs and endocrine FGFs that activate four receptor tyrosine …

[HTML][HTML] Gene editing and its applications in biomedicine

G Li, X Li, S Zhuang, L Wang, Y Zhu, Y Chen… - Science China Life …, 2022 - Springer
The steady progress in genome editing, especially genome editing based on the use of
clustered regularly interspaced short palindromic repeats (CRISPR) and programmable …

[HTML][HTML] Single-cell analysis of lizard blastema fibroblasts reveals phagocyte-dependent activation of Hedgehog-responsive chondrogenesis

AC Vonk, X Zhao, Z Pan, ML Hudnall… - Nature …, 2023 - nature.com
Lizards cannot naturally regenerate limbs but are the closest known relatives of mammals
capable of epimorphic tail regrowth. However, the mechanisms regulating lizard blastema …

[HTML][HTML] The salamander blastema within the broader context of metazoan regeneration

B Tajer, AM Savage, JL Whited - Frontiers in Cell and Developmental …, 2023 - frontiersin.org
Throughout the animal kingdom regenerative ability varies greatly from species to species,
and even tissue to tissue within the same organism. The sheer diversity of structures and …

Validation of a zebrafish developmental defects assay as a qualified alternative test for its regulatory use following the ICH S5 (R3) guideline

AMJ Weiner, I Irijalba, MP Gallego, I Ibarburu… - Reproductive …, 2024 - Elsevier
Zebrafish is a popular toxicology model and provides an ethically acceptable small-scale
analysis system with the complexity of a complete organism. Our goal is to further validate …

Spatial transcriptomics reveals asymmetric cellular responses to injury in the regenerating spiny mouse (Acomys) ear

H van Beijnum, T Koopmans, A Tomasso… - Genome …, 2023 - genome.cshlp.org
In contrast to other mammals, the spiny mouse (Acomys) regenerates skin and ear tissue,
which includes hair follicles, glands, and cartilage, in a scar-free manner. Ear punch …

[HTML][HTML] Comparative study in zebrafish and medaka unravels the mechanisms of tissue regeneration

K Chowdhury, S Lin, SL Lai - Frontiers in Ecology and Evolution, 2022 - frontiersin.org
Tissue regeneration has been in the spotlight of research for its fascinating nature and
potential applications in human diseases. The trait of regenerative capacity occurs diversely …

Musculoskeletal regeneration: A zebrafish perspective

AK Kaliya-Perumal, PW Ingham - Biochimie, 2022 - Elsevier
Musculoskeletal injuries are common in humans. The cascade of cellular and molecular
events following such injuries results either in healing with functional recovery or scar …

[HTML][HTML] Comprehensive characterization of tissues derived from animals at different regenerative stages: a comparative analysis between fetal and adult mouse skin

V Castillo, P Díaz-Astudillo, R Corrales-Orovio… - Cells, 2023 - mdpi.com
Tissue regeneration capabilities vary significantly throughout an organism's lifespan. For
example, mammals can fully regenerate until they reach specific developmental stages, after …

Antler tine homologies and cervid systematics: A review of past and present controversies with special emphasis on Elaphurus davidianus

NS Heckeberg, FE Zachos… - The Anatomical Record, 2023 - Wiley Online Library
Antlers are the most conspicuous trait of cervids and have been used in the past to establish
a classification of their fossil and living representatives. Since the availability of molecular …