New developments in the biology of fibroblast growth factors
DM Ornitz, N Itoh - WIREs mechanisms of disease, 2022 - Wiley Online Library
The fibroblast growth factor (FGF) family is composed of 18 secreted signaling proteins
consisting of canonical FGFs and endocrine FGFs that activate four receptor tyrosine …
consisting of canonical FGFs and endocrine FGFs that activate four receptor tyrosine …
[HTML][HTML] Gene editing and its applications in biomedicine
G Li, X Li, S Zhuang, L Wang, Y Zhu, Y Chen… - Science China Life …, 2022 - Springer
The steady progress in genome editing, especially genome editing based on the use of
clustered regularly interspaced short palindromic repeats (CRISPR) and programmable …
clustered regularly interspaced short palindromic repeats (CRISPR) and programmable …
[HTML][HTML] Single-cell analysis of lizard blastema fibroblasts reveals phagocyte-dependent activation of Hedgehog-responsive chondrogenesis
AC Vonk, X Zhao, Z Pan, ML Hudnall… - Nature …, 2023 - nature.com
Lizards cannot naturally regenerate limbs but are the closest known relatives of mammals
capable of epimorphic tail regrowth. However, the mechanisms regulating lizard blastema …
capable of epimorphic tail regrowth. However, the mechanisms regulating lizard blastema …
[HTML][HTML] The salamander blastema within the broader context of metazoan regeneration
Throughout the animal kingdom regenerative ability varies greatly from species to species,
and even tissue to tissue within the same organism. The sheer diversity of structures and …
and even tissue to tissue within the same organism. The sheer diversity of structures and …
Validation of a zebrafish developmental defects assay as a qualified alternative test for its regulatory use following the ICH S5 (R3) guideline
AMJ Weiner, I Irijalba, MP Gallego, I Ibarburu… - Reproductive …, 2024 - Elsevier
Zebrafish is a popular toxicology model and provides an ethically acceptable small-scale
analysis system with the complexity of a complete organism. Our goal is to further validate …
analysis system with the complexity of a complete organism. Our goal is to further validate …
Spatial transcriptomics reveals asymmetric cellular responses to injury in the regenerating spiny mouse (Acomys) ear
H van Beijnum, T Koopmans, A Tomasso… - Genome …, 2023 - genome.cshlp.org
In contrast to other mammals, the spiny mouse (Acomys) regenerates skin and ear tissue,
which includes hair follicles, glands, and cartilage, in a scar-free manner. Ear punch …
which includes hair follicles, glands, and cartilage, in a scar-free manner. Ear punch …
[HTML][HTML] Comparative study in zebrafish and medaka unravels the mechanisms of tissue regeneration
Tissue regeneration has been in the spotlight of research for its fascinating nature and
potential applications in human diseases. The trait of regenerative capacity occurs diversely …
potential applications in human diseases. The trait of regenerative capacity occurs diversely …
Musculoskeletal regeneration: A zebrafish perspective
AK Kaliya-Perumal, PW Ingham - Biochimie, 2022 - Elsevier
Musculoskeletal injuries are common in humans. The cascade of cellular and molecular
events following such injuries results either in healing with functional recovery or scar …
events following such injuries results either in healing with functional recovery or scar …
[HTML][HTML] Comprehensive characterization of tissues derived from animals at different regenerative stages: a comparative analysis between fetal and adult mouse skin
V Castillo, P Díaz-Astudillo, R Corrales-Orovio… - Cells, 2023 - mdpi.com
Tissue regeneration capabilities vary significantly throughout an organism's lifespan. For
example, mammals can fully regenerate until they reach specific developmental stages, after …
example, mammals can fully regenerate until they reach specific developmental stages, after …
Antler tine homologies and cervid systematics: A review of past and present controversies with special emphasis on Elaphurus davidianus
NS Heckeberg, FE Zachos… - The Anatomical Record, 2023 - Wiley Online Library
Antlers are the most conspicuous trait of cervids and have been used in the past to establish
a classification of their fossil and living representatives. Since the availability of molecular …
a classification of their fossil and living representatives. Since the availability of molecular …