Arrhythmogenic cardiomyopathy is a genetic disorder characterized by the risk of life-
threatening arrhythmias, myocardial dysfunction and fibrofatty replacement of myocardial …

Background: Plakophilin-2 (PKP2) is classically defined as a desmosomal protein. Mutations
in PKP2 associate with most cases of gene-positive arrhythmogenic right ventricular …

Background Pathogenic variants in the filamin C (FLNC) gene are associated with inherited
cardiomyopathies including dilated cardiomyopathy with an arrhythmogenic phenotype. We …

Rationale: Sequence variation, methylation differences, and transcriptional changes in
desmoplakin (DSP) have been observed in patients with idiopathic pulmonary fibrosis (IPF) …

Desmoplakin (DP) is an obligate component of desmosomes, intercellular adhesive
junctions that maintain the integrity of the epidermis and myocardium. Mutations in DP can …

Intermediate filament (IF) attachment to intercellular junctions is required for skin and heart
integrity, but how the strength and dynamics of this attachment are modulated during normal …

Telocytes (TC s) were recently described as interstitial cells with very long prolongations
named telopodes (Tps; www. telocytes. com). Establishing the TC proteome is a priority to …

Rationale: DSP (desmoplakin), the most abundant component of desmosomes, which
maintain the mechanical integrity of epithelium, is a genome-wide association study …

Background Arrhythmogenic cardiomyopathy (AC) is a myocardial disease due to
desmosomal mutations whose pathogenesis is incompletely understood. Objective The …

Progressive loss of cardiac systolic function in arrhythmogenic cardiomyopathy (ACM) has
recently gained attention as an important clinical consideration in managing the disease …