Synaptic activity initiates biochemical processes that have various outcomes, including the
formation of memories, increases in neuronal survival and the development of chronic pain …

Freund, Tamás F., István Katona, and Daniele Piomelli. Role of Endogenous Cannabinoids
in Synaptic Signaling. Physiol Rev 83: 1017–1066, 2003; 10.1152/physrev. 00004.2003 …

Studies on control of fluid secretion by an insect salivary gland led to the discovery of inositol
trisphosphate (IP3) and its role in calcium signalling. Many cell stimuli act on receptors that …

The endoplasmic reticulum (ER) is a multifunctional signaling organelle that controls a wide
range of cellular processes such as the entry and release of Ca2+, sterol biosynthesis …

The endoplasmic reticulum (ER) is the largest single intracellular organelle, which is present
in all types of nerve cells. The ER is an interconnected, internally continuous system of …

All cells use changes in intracellular calcium concentration ([Ca2+] i) to regulate cell
signalling events. In neurons, with their elaborate dendritic and axonal arborizations, there …

Acetylcholine is an essential excitatory neurotransmitter in the central nervous system and
undertakes a vital role in cognitive function. Consequently, there is ample evidence to …

Cholinergic septohippocampal projections from the medial septal area to the hippocampus
are proposed to have important roles in cognition by modulating properties of the …

Background Scopolamine is a well-known cholinergic antagonist that causes amnesia in
human and animal models. Scopolamine-induced amnesia in rodent models has been …

Learning induces plastic changes in synapses. However, the regulatory molecules that
orchestrate learning-induced synaptic changes are largely unknown. Although it is well …