The complement cascade is a critical effector mechanism of the innate immune system that
contributes to the rapid clearance of pathogens and dead or dying cells, as well as …

Microglia, brain resident immune cells, modulate development, activity, and plasticity of the
central nervous system. Mechanistically implicated in numerous neurological pathologies …

Vascular contributions to cognitive impairment and dementia (VCID) is an all-encompassing
term that describes cognitive impairment due to cerebrovascular origins. With the …

Background: Inflammation is proposed to be involved in the pathogenesis of poststroke
cognitive impairment. The aim of this study was to investigate associations between …

In vitro and preclinical in vivo research in the last 35 years has clearly highlighted the crucial
physiopathological role of glial cells, namely astrocytes/microglia/oligodendrocytes and …

Inter-α inhibitor proteins (IAIPs) are a family of endogenous plasma and extracellular matrix
molecules. IAIPs suppress proinflammatory cytokines, limit excess complement activation …

Ischaemic stroke remains a leading cause of disability, with current clinical treatment options
mainly focusing on mitigating immediate damage. The limited self-renewing capacity of the …

Over the last decade there have been numerous advances in both the diagnosis and
treatment of transplant‐associated thrombotic microangiopathy (TA‐TMA). These are largely …

Neuroprotection to attenuate or block the ischemic cascade and salvage neuronal damage
has been extensively explored for treating ischemic stroke. However, despite increasing …

The complement system is implicated in a broad range of neuroinflammatory disorders such
as Alzheimer's disease (AD) and multiple sclerosis (MS). Consequently, measuring …