COVID-19 mortality is strongly associated with the development of severe pneumonia and
acute respiratory distress syndrome with the worst outcome resulting in cytokine release …

Hydroxychloroquine and chloroquine are medications that have been used for a long time.
Their most common use is for the treatment and prophylaxis of malaria. However, these …

Our recently published research on the characterization of vesicular stomatitis virus (VSV)
pathogenesis in swine, identified a systemic upregulation of interleukin 6 (IL-6) during the …

Photodynamic therapy (PDT) is ineffective against deeply seated metastatic tumors due to
poor penetration of the excitation light. Herein, we developed a biomimetic nanoreactor (bio …

The global spread of SARS-CoV-2 requires an urgent need to find effective therapeutics for
the treatment of COVID-19. We developed a data-driven drug repositioning framework …

Loss of p53 function contributes to the development of many cancers. While cell-
autonomous consequences of p53 mutation have been studied extensively, the role of p53 …

COVID-19 has emerged as a global pandemic. It is mainly manifested as pneumonia which
may deteriorate into severe respiratory failure. The major hallmark of the disease is the …

Abstract Interleukin-6 (IL-6), known as an inflammatory cytokine, can be involved in many
innate and adaptive immune responses. The role of IL-6 in the pathogenesis of the novel …

The global spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
requires an urgent need to find effective therapeutics for the treatment of coronavirus …

T-cell recognition of cancer neoantigens is important for effective immune-checkpoint
blockade therapy, and an increasing interest exists in developing personalized tumor …