Throughout the biological world, a 30 Å hydrophobic film typically delimits the environments
that serve as the margin between life and death for individual cells. Biochemical and …

About twenty years ago, the functional lipid raft model of the plasma membrane was
published. It took into account decades of research showing that cellular membranes are not …

Obesity is associated with an enhanced inflammatory response that exacerbates insulin
resistance and contributes to diabetes, atherosclerosis, and cardiovascular disease. One …

Ceramides are involved in a variety of cellular processes and in disease. Their biological
functions are thought to depend on ceramides' unique biophysical properties, which …

Ceramides are a heterogeneous group of bioactive membrane sphingolipids that play
specialized regulatory roles in cellular metabolism depending on their characteristic fatty …

Focal segmental glomerulosclerosis (FSGS) is a glomerular disease characterized by
proteinuria, progression to end-stage renal disease, and recurrence of proteinuria after …

Abnormal sphingolipid metabolism has been previously reported in Alzheimer's disease
(AD). To extend these findings, several sphingolipids and sphingolipid hydrolases were …

Inflammation is a network of complex processes involving a variety of metabolic and
signaling pathways aiming at healing and repairing damage tissue, or fighting infection …

Molecular analysis on the single-cell level represents a rapidly growing field in the life
sciences. While bulk analysis from a pool of cells provides a general molecular profile, it is …

Ceramide, the precursor of all complex sphingolipids, is a potent signaling molecule that
mediates key events of cellular pathophysiology. In the nervous system, the sphingolipid …