[HTML][HTML] Endoplasmic reticulum stress and mitochondrial stress in drug-induced liver injury
S Pu, Y Pan, Q Zhang, T You, T Yue, Y Zhang, M Wang - Molecules, 2023 - mdpi.com
Drug-induced liver injury (DILI) is a widespread and harmful disease closely linked to
mitochondrial and endoplasmic reticulum stress (ERS). Globally, severe drug-induced …
mitochondrial and endoplasmic reticulum stress (ERS). Globally, severe drug-induced …
[HTML][HTML] Clinically relevant therapeutic approaches against acetaminophen hepatotoxicity and acute liver failure
Liver injury and acute liver failure caused by an acetaminophen (APAP) overdose is a
significant clinical problem in western countries. With the introduction of the mouse model of …
significant clinical problem in western countries. With the introduction of the mouse model of …
Nrf2 as a therapeutic target in acetaminophen hepatotoxicity: A case study with sulforaphane
Acetaminophen (APAP) overdose can cause severe liver injury and acute liver failure. The
only clinically approved antidote, N‐acetylcysteine (NAC), is highly effective but has a …
only clinically approved antidote, N‐acetylcysteine (NAC), is highly effective but has a …
[HTML][HTML] The essential role of O-GlcNAcylation in hepatic differentiation
DR Robarts, M Kotulkar, D Paine-Cabrera… - Hepatology …, 2023 - journals.lww.com
Background: O-GlcNAcylation is a post-translational modification catalyzed by the enzyme O-
GlcNAc transferase, which transfers a single N-acetylglucosamine sugar from UDP-GlcNAc …
GlcNAc transferase, which transfers a single N-acetylglucosamine sugar from UDP-GlcNAc …
Biomarker discovery in acetaminophen hepatotoxicity: leveraging single-cell transcriptomics and mechanistic insight
DS Umbaugh, H Jaeschke - Expert Review of Clinical …, 2024 - Taylor & Francis
Introduction Acetaminophen (APAP) overdose is the leading cause of drug-induced liver
injury and can cause a rapid progression to acute liver failure (ALF). Therefore, the …
injury and can cause a rapid progression to acute liver failure (ALF). Therefore, the …
[HTML][HTML] Identifying Human Specific Adverse Outcome Pathways of Per-and Polyfluoroalkyl Substances Using Liver-Chimeric Humanized Mice
DR Robarts, D Paine-Cabrera, M Kotulkar… - bioRxiv, 2023 - ncbi.nlm.nih.gov
Background Per-and polyfluoroalkyl substances (PFAS) are persistent organic pollutants
with myriad adverse effects. While perfluorooctanoic acid (PFOA) and perfluorooctane …
with myriad adverse effects. While perfluorooctanoic acid (PFOA) and perfluorooctane …