Cellular mechanotransduction, a critical regulator of numerous biological processes, is the
conversion from mechanical signals to biochemical signals regarding cell activities and …

Idiopathic pulmonary fibrosis (IPF) is a progressive, lethal fibrotic lung disease that occurs
primarily in middle-aged and elderly adults. It is a major cause of morbidity and mortality …

Mechanical damage is one of the predisposing factors of inflammation, and it runs through
the entire inflammatory pathological process. Repeated or persistent damaging mechanical …

Pulmonary fibrosis (PF) is a serious and progressive lung disease which is possibly life-
threatening. It causes lung scarring and affects lung functions including epithelial cell injury …

It is widely accepted that three-dimensional cell culture systems simulate physiological
conditions better than traditional 2D systems. Although extracellular matrix components …

Mechanical cues in the cell microenvironment such as those from extracellular matrix
properties, stretching, compression and shear stress, play a critical role in maintaining …

The ability of cells to sense and respond to changes in mechanical environment is vital in
conditions of organ injury when the architecture of normal tissues is disturbed or lost. Among …

It is reported that pulmonary fibrosis has become one of the major long-term complications of
COVID-19, even in asymptomatic individuals. Currently, despite the best efforts of the global …

The biomechanical properties of extracellular matrices (ECM) and their consequences for
cellular homeostasis have recently emerged as a driver of aging. Here we review the age …

Fibrosis is the abnormal deposition of extracellular matrix, characterized by accumulation of
collagen and other extracellular matrix components, which causes organ dysfunction and …