Functionalizing DNA origami to investigate and interact with biological systems
DNA origami has emerged as a powerful method to generate DNA nanostructures with
dynamic properties and nanoscale control. These nanostructures enable complex …
dynamic properties and nanoscale control. These nanostructures enable complex …
Trends and patterns in cancer nanotechnology research: A survey of NCI's caNanoLab and nanotechnology characterization laboratory
W Ke, RM Crist, JD Clogston, ST Stern… - Advanced drug delivery …, 2022 - Elsevier
Cancer nanotechnologies possess immense potential as therapeutic and diagnostic
treatment modalities and have undergone significant and rapid advancement in recent …
treatment modalities and have undergone significant and rapid advancement in recent …
RNA four-way junction (4WJ) for spontaneous cancer-targeting, effective tumor-regression, metastasis suppression, fast renal excretion and undetectable toxicity
The field of RNA therapeutics has been emerging as the third milestone in pharmaceutical
drug development. RNA nanoparticles have displayed motile and deformable properties to …
drug development. RNA nanoparticles have displayed motile and deformable properties to …
Micro and nanotechnologies: The little formulations that could
RT Stiepel, E Duggan, CJ Batty… - … & Translational Medicine, 2023 - Wiley Online Library
The first publication of micro‐and nanotechnology in medicine was in 1798 with the use of
the Cowpox virus by Edward Jenner as an attenuated vaccine against Smallpox. Since then …
the Cowpox virus by Edward Jenner as an attenuated vaccine against Smallpox. Since then …
Controlling nuclease degradation of wireframe DNA origami with minor groove binders
Viruslike particles (VLPs) fabricated using wireframe DNA origami are emerging as
promising vaccine and gene therapeutic delivery platforms due to their programmable …
promising vaccine and gene therapeutic delivery platforms due to their programmable …
Artificial Immune Cell, AI‐cell, a New Tool to Predict Interferon Production by Peripheral Blood Monocytes in Response to Nucleic Acid Nanoparticles
M Chandler, S Jain, J Halman, E Hong… - Small, 2022 - Wiley Online Library
Nucleic acid nanoparticles, or NANPs, rationally designed to communicate with the human
immune system, can offer innovative therapeutic strategies to overcome the limitations of …
immune system, can offer innovative therapeutic strategies to overcome the limitations of …
Expanding structural space for immunomodulatory nucleic acid nanoparticles via spatial arrangement of their therapeutic moieties
Different therapeutic nucleic acids (TNAs) can be unified in a single structure by their
elongation with short oligonucleotides designed to self‐assemble into nucleic acid …
elongation with short oligonucleotides designed to self‐assemble into nucleic acid …
In Vitro and In Vivo Evaluation of the Pathology and Safety Aspects of Three- and Four-Way Junction RNA Nanoparticles
RNA therapeutics has advanced into the third milestone in pharmaceutical drug
development, following chemical and protein therapeutics. RNA itself can serve as …
development, following chemical and protein therapeutics. RNA itself can serve as …
Nucleic acid nanostructures for in vivo applications: The influence of morphology on biological fate
The development of programmable biomaterials for use in nanofabrication represents a
major advance for the future of biomedicine and diagnostics. Recent advances in structural …
major advance for the future of biomedicine and diagnostics. Recent advances in structural …
[HTML][HTML] Therapeutic immunomodulation by rationally designed nucleic acids and nucleic acid nanoparticles
The immune system has evolved to defend organisms against exogenous threats such as
viruses, bacteria, fungi, and parasites by distinguishing between “self” and “non-self”. In …
viruses, bacteria, fungi, and parasites by distinguishing between “self” and “non-self”. In …