Tuberculosis: progress and advances in development of new drugs, treatment regimens, and host-directed therapies

S Tiberi, N du Plessis, G Walzl, MJ Vjecha… - The Lancet Infectious …, 2018 - thelancet.com
Tuberculosis remains the world's leading cause of death from an infectious disease,
responsible for an estimated 1 674 000 deaths annually. WHO estimated 600 000 cases of …

Vaccines against antimicrobial resistance

R Rosini, S Nicchi, M Pizza, R Rappuoli - Frontiers in immunology, 2020 - frontiersin.org
In the last century, life expectancy has increased considerably, thanks to the introduction of
antibiotics, hygiene and vaccines that have contributed to the cure and prevention of many …

Recent advances in the treatment of tuberculosis

I Motta, M Boeree, D Chesov, K Dheda… - Clinical Microbiology …, 2023 - Elsevier
Background Tuberculosis (TB) is a global health challenge and one of the leading causes of
death worldwide. In the last decade, the TB treatment landscape has dramatically changed …

Principles for constructing a tuberculosis treatment regimen: the role and definition of core and companion drugs

A Van Deun, T Decroo, A Piubello… - … of Tuberculosis and …, 2018 - ingentaconnect.com
Current World Health Organization guidelines for the formulation of treatment regimens for
multidrug-resistant tuberculosis (MDR-TB) pay too little attention to the microbiological …

Mannose-Functionalized Isoniazid-Loaded Nanostructured Lipid Carriers for Pulmonary Delivery: In Vitro Prospects and In Vivo Therapeutic Efficacy Assessment

S Ahalwat, DC Bhatt, S Rohilla, V Jogpal, K Sharma… - Pharmaceuticals, 2023 - mdpi.com
Resistance to isoniazid (INH) is common and increases the possibility of acquiring multidrug-
resistant tuberculosis. For this study, isoniazid-loaded nanostructured lipid carriers (INH …

[HTML][HTML] New and repurposed drugs to treat multidrug-and extensively drug-resistant tuberculosis

DR Silva, M Dalcolmo, S Tiberi, MA Arbex… - Jornal Brasileiro de …, 2018 - SciELO Brasil
Multidrug-resistant and extensively drug-resistant tuberculosis (MDR-TB and XDR-TB,
respectively) continue to represent a challenge for clinicians and public health authorities …

Novel approaches for the treatment of pulmonary tuberculosis

ZM Tan, GP Lai, M Pandey, T Srichana, MR Pichika… - Pharmaceutics, 2020 - mdpi.com
Tuberculosis (TB) is a contagious airborne disease caused by Mycobacterium tuberculosis,
which primarily affects human lungs. The progression of drug-susceptible TB to drug …

[HTML][HTML] Treatment of isoniazid-resistant pulmonary tuberculosis

BW Jhun, WJ Koh - Tuberculosis and Respiratory Diseases, 2020 - synapse.koreamed.org
Tuberculosis (TB) remains a threat to public health and is the leading cause of death
globally. Isoniazid (INH) is an important first-line agent for the treatment of TB considering its …

Tuberculous meningitis in children and adults: new insights for an ancient foe

A Mezochow, K Thakur, C Vinnard - Current neurology and neuroscience …, 2017 - Springer
Abstract Purpose of Review Tuberculous meningitis is the most devastating manifestation of
infection with Mycobacterium tuberculosis and represents a medical emergency …

Isoniazid linked to sulfonate esters via hydrazone functionality: design, synthesis, and evaluation of antitubercular activity

E Koçak Aslan, Mİ Han, VS Krishna, R Tamhaev… - Pharmaceuticals, 2022 - mdpi.com
Isoniazid (INH) is one of the key molecules employed in the treatment of tuberculosis (TB),
the most deadly infectious disease worldwide. However, the efficacy of this cornerstone drug …