Intermittent and periodic fasting, longevity and disease

VD Longo, M Di Tano, MP Mattson, N Guidi - Nature aging, 2021 - nature.com
Intermittent and periodic fasting (IF and PF, respectively) are emerging as safe strategies to
affect longevity and healthspan by acting on cellular aging and disease risk factors, while …

Decreased serum brain-derived neurotrophic factor (BDNF) levels in patients with Alzheimer's disease (AD): a systematic review and meta-analysis

TKS Ng, CSH Ho, WWS Tam, EH Kua… - International journal of …, 2019 - mdpi.com
Findings from previous studies reporting the levels of serum brain-derived neurotrophic
factor (BDNF) in patients with Alzheimer's disease (AD) and individuals with mild cognitive …

[HTML][HTML] Metformin restores CNS remyelination capacity by rejuvenating aged stem cells

B Neumann, R Baror, C Zhao, M Segel, S Dietmann… - Cell stem cell, 2019 - cell.com
The age-related failure to produce oligodendrocytes from oligodendrocyte progenitor cells
(OPCs) is associated with irreversible neurodegeneration in multiple sclerosis (MS) …

Mitochondria as central regulators of neural stem cell fate and cognitive function

M Khacho, R Harris, RS Slack - Nature Reviews Neuroscience, 2019 - nature.com
Emerging evidence now indicates that mitochondria are central regulators of neural stem
cell (NSC) fate decisions and are crucial for both neurodevelopment and adult …

Neurogenesis in aging and age-related neurodegenerative diseases

L Culig, X Chu, VA Bohr - Ageing research reviews, 2022 - Elsevier
Adult neurogenesis, the process by which neurons are generated in certain areas of the
adult brain, declines in an age-dependent manner and is one potential target for extending …

[HTML][HTML] Nutritional factors affecting adult neurogenesis and cognitive function

SM Poulose, MG Miller, T Scott, B Shukitt-Hale - Advances in nutrition, 2017 - Elsevier
Adult neurogenesis, a complex process by which stem cells in the hippocampal brain region
differentiate and proliferate into new neurons and other resident brain cells, is known to be …

Potential therapeutic uses of BDNF in neurological and psychiatric disorders

AH Nagahara, MH Tuszynski - Nature reviews Drug discovery, 2011 - nature.com
The growth factor brain-derived neurotrophic factor (BDNF) and its receptor tropomyosin-
related kinase receptor type B (TRKB) are actively produced and trafficked in multiple …

Apoptosis in neurodegenerative disorders

MP Mattson - Nature reviews Molecular cell biology, 2000 - nature.com
Neuronal death underlies the symptoms of many human neurological disorders, including
Alzheimer's, Parkinson's and Huntington's diseases, stroke, and amyotrophic lateral …

Factors that influence adult neurogenesis as potential therapy

B Shohayeb, M Diab, M Ahmed, DCH Ng - Translational …, 2018 - Springer
Adult neurogenesis involves persistent proliferative neuroprogenitor populations that reside
within distinct regions of the brain. This phenomenon was first described over 50 years ago …

Evidence that brain‐derived neurotrophic factor is required for basal neurogenesis and mediates, in part, the enhancement of neurogenesis by dietary restriction in the …

J Lee, W Duan, MP Mattson - Journal of neurochemistry, 2002 - Wiley Online Library
To determine the role of brain‐derived neurotrophic factor (BDNF) in the enhancement of
hippocampal neurogenesis resulting from dietary restriction (DR), heterozygous BDNF …